Software tools for identification, visualization and analysis of protein tunnels and channels

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F13%3A00065808" target="_blank" >RIV/00216224:14310/13:00065808 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/13:00063742

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.biotechadv.2012.02.002" target="_blank" >http://dx.doi.org/10.1016/j.biotechadv.2012.02.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biotechadv.2012.02.002" target="_blank" >10.1016/j.biotechadv.2012.02.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Software tools for identification, visualization and analysis of protein tunnels and channels

Popis výsledku v původním jazyce

Protein structures contain highly complex systems of voids, making up specific features such as surface clefts or grooves, pockets, protrusions, cavities, pores or channels, and tunnels. Many of them are essential for the migration of solvents, ions andsmall molecules through proteins, and their binding to the functional sites. Analysis of these structural features is very important for understanding of structure-function relationships, for the design of potential inhibitors or proteins with improved functional properties. Here we critically review existing software tools specialized in rapid identification, visualization, analysis and design of protein tunnels and channels. The strengths and weaknesses of individual tools are reported together with examples of their applications for the analysis and engineering of various biological systems.

Název v anglickém jazyce

Software tools for identification, visualization and analysis of protein tunnels and channels

Popis výsledku anglicky

Protein structures contain highly complex systems of voids, making up specific features such as surface clefts or grooves, pockets, protrusions, cavities, pores or channels, and tunnels. Many of them are essential for the migration of solvents, ions andsmall molecules through proteins, and their binding to the functional sites. Analysis of these structural features is very important for understanding of structure-function relationships, for the design of potential inhibitors or proteins with improved functional properties. Here we critically review existing software tools specialized in rapid identification, visualization, analysis and design of protein tunnels and channels. The strengths and weaknesses of individual tools are reported together with examples of their applications for the analysis and engineering of various biological systems.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BIOTECHNOLOGY ADVANCES

ISSN

0734-9750

e-ISSN

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Svazek periodika

31

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

38-49

Kód UT WoS článku

000315761200004

EID výsledku v databázi Scopus

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