Capillary electrophoresis with contactless conductivity detection for amino acid profiling of human plasma and urine samples
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F13%3A00066540" target="_blank" >RIV/00216224:14310/13:00066540 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Capillary electrophoresis with contactless conductivity detection for amino acid profiling of human plasma and urine samples
Popis výsledku v původním jazyce
The results of method development for amino acid profiling of biological fluids, namely human plasma and urine, were presented. Optimization steps of the method and sample treatment protocol were discussed and the method suitability for amino acid profiling was tested on analysis of human plasma and urine samples. There were analyzed 26 human plasma samples varying in age, sex and diagnosis were analyzed giving highly divergent statistical sample. Principal component analysis showed a partial grouping of diagnoses based on amino acid profiles. Human urine samples were collected from women selected to form a non-divergent statistical sample. There were found statistically significant differences in the levels of amino acids between healthy women and woman suffering from epileptic seizures.
Název v anglickém jazyce
Capillary electrophoresis with contactless conductivity detection for amino acid profiling of human plasma and urine samples
Popis výsledku anglicky
The results of method development for amino acid profiling of biological fluids, namely human plasma and urine, were presented. Optimization steps of the method and sample treatment protocol were discussed and the method suitability for amino acid profiling was tested on analysis of human plasma and urine samples. There were analyzed 26 human plasma samples varying in age, sex and diagnosis were analyzed giving highly divergent statistical sample. Principal component analysis showed a partial grouping of diagnoses based on amino acid profiles. Human urine samples were collected from women selected to form a non-divergent statistical sample. There were found statistically significant differences in the levels of amino acids between healthy women and woman suffering from epileptic seizures.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GAP206%2F11%2F0009" target="_blank" >GAP206/11/0009: Kapilární electroforéza jako nástroj pro metabolomické studie</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Chemické listy
ISSN
0009-2770
e-ISSN
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Svazek periodika
107
Číslo periodika v rámci svazku
S3
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
2
Strana od-do
318-319
Kód UT WoS článku
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EID výsledku v databázi Scopus
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