Patterns of selection on Plasmodium falciparum erythrocyte binding antigens after the colonisation of the New World

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F14%3A00075087" target="_blank" >RIV/00216224:14310/14:00075087 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1111/mec.12696/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/mec.12696/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/mec.12696" target="_blank" >10.1111/mec.12696</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Patterns of selection on Plasmodium falciparum erythrocyte binding antigens after the colonisation of the New World

Popis výsledku v původním jazyce

Pathogens, which have recently colonized a new host species or new populations of the same host, are interesting models for understanding how populations may evolve in response to novel environments. During its colonization of South America from Africa Plasmodium falciparum, the main agent of malaria, has been exposed to new conditions in distinctive new human populations (Amerindian and populations of mixed origins), that likely exerted new selective pressures on the parasite's genome. Among the genesthat might have experienced strong selective pressures in response to these environmental changes, the eba genes (erythrocyte binding antigens genes), which are involved in the invasion of the human red blood cells, constitute good candidates. In this study, we analyzed, in South America, the polymorphism of three eba genes (eba-140, eba-175, eba-181) and compared it to the polymorphism observed in African populations.

Název v anglickém jazyce

Patterns of selection on Plasmodium falciparum erythrocyte binding antigens after the colonisation of the New World

Popis výsledku anglicky

Pathogens, which have recently colonized a new host species or new populations of the same host, are interesting models for understanding how populations may evolve in response to novel environments. During its colonization of South America from Africa Plasmodium falciparum, the main agent of malaria, has been exposed to new conditions in distinctive new human populations (Amerindian and populations of mixed origins), that likely exerted new selective pressures on the parasite's genome. Among the genesthat might have experienced strong selective pressures in response to these environmental changes, the eba genes (erythrocyte binding antigens genes), which are involved in the invasion of the human red blood cells, constitute good candidates. In this study, we analyzed, in South America, the polymorphism of three eba genes (eba-140, eba-175, eba-181) and compared it to the polymorphism observed in African populations.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EG - Zoologie

OECD FORD obor

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Projekt

<a href="/cs/project/EE2.3.30.0009" target="_blank" >EE2.3.30.0009: Zaměstnáním čerstvých absolventů doktorského studia k vědecké excelenci</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular Ecology

ISSN

0962-1083

e-ISSN

—

Svazek periodika

23

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

1979-1993

Kód UT WoS článku

000333858200008

EID výsledku v databázi Scopus

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