Complete genome analysis of two new bacteriophages isolated from impetigo strains of Staphylococcus aureus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00080938" target="_blank" >RIV/00216224:14310/15:00080938 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00027162:_____/15:#0001295 RIV/75010330:_____/15:00010928

Výsledek na webu

<a href="http://link.springer.com/article/10.1007%2Fs11262-015-1223-8" target="_blank" >http://link.springer.com/article/10.1007%2Fs11262-015-1223-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11262-015-1223-8" target="_blank" >10.1007/s11262-015-1223-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Complete genome analysis of two new bacteriophages isolated from impetigo strains of Staphylococcus aureus

Popis výsledku v původním jazyce

Exfoliative toxin A (ETA)-coding temperate bacteriophages are leading contributors to the toxic phenotype of impetigo strains of Staphylococcus aureus. Two distinct eta gene-positive bacteriophages isolated from S. aureus strains which recently caused massive outbreaks of pemphigus neonatorum in Czech maternity hospitals were characterized. The phages, designated B166 and B236, were able to transfer the eta gene into a prophageless S. aureus strain which afterwards converted into an ETA producer. Complete phage genome sequences were determined, and a comparative analysis of five designed genomic regions revealed major variances between them. They differed in the genome size, number of open reading frames, genome architecture, and virion protein patterns. Their high mutual sequence similarity was detected only in the terminal regions of the genome. When compared with the so far described eta phage genomes, noticeable differences were found.

Název v anglickém jazyce

Complete genome analysis of two new bacteriophages isolated from impetigo strains of Staphylococcus aureus

Popis výsledku anglicky

Exfoliative toxin A (ETA)-coding temperate bacteriophages are leading contributors to the toxic phenotype of impetigo strains of Staphylococcus aureus. Two distinct eta gene-positive bacteriophages isolated from S. aureus strains which recently caused massive outbreaks of pemphigus neonatorum in Czech maternity hospitals were characterized. The phages, designated B166 and B236, were able to transfer the eta gene into a prophageless S. aureus strain which afterwards converted into an ETA producer. Complete phage genome sequences were determined, and a comparative analysis of five designed genomic regions revealed major variances between them. They differed in the genome size, number of open reading frames, genome architecture, and virion protein patterns. Their high mutual sequence similarity was detected only in the terminal regions of the genome. When compared with the so far described eta phage genomes, noticeable differences were found.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Virus Genes

ISSN

0920-8569

e-ISSN

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Svazek periodika

51

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

122-131

Kód UT WoS článku

000358548500015

EID výsledku v databázi Scopus

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