EFFECTS OF FLUOXETINE ON THYROID HORMONES METABOLISM

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00116082" target="_blank" >RIV/00216224:14310/15:00116082 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/15:00472836

Výsledek na webu

<a href="https://www.rad-conference.org/pdf/Proceedings%20RAD%202015.pdf" target="_blank" >https://www.rad-conference.org/pdf/Proceedings%20RAD%202015.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

EFFECTS OF FLUOXETINE ON THYROID HORMONES METABOLISM

Popis výsledku v původním jazyce

In studies of the interaction of an antidepressant drug fluoxetine (Fluox) with the metabolism of thyroid hormones (TH) in the rat, we applied our newly developed radiometric assays for iodothyronine deiodinases (IDs) of types 1, 2 and 3 (D1, D2 and D3, respectively), using [125I]-labeled iodothyronines of high specific radioactivity as substrates. We followed in details the effects of administration during 25 days to adult Wistar rats of Fluox alone or in combination with triiodothyronine (T-3) on the production and degradation of TH in the CNS and in different peripheral rat tissues. Surprisingly, administration of Fluox in combination with supraphysiological amounts of T-3 caused a distinctive fall of non-physiologically high concentrations of serum total T-3, which were reached by giving the animals the same amounts of T-3 alone, to nearly normal levels. Profound changes in IDs enzyme activities were determined, especially in the pituitary and cerebellum of treated rats. In conclusion, the elaborated radiometric assays for IDs were found to be usable for the assessment of changes in these enzyme activities, caused by the administration of the studied drugs to the rats.

Název v anglickém jazyce

EFFECTS OF FLUOXETINE ON THYROID HORMONES METABOLISM

Popis výsledku anglicky

In studies of the interaction of an antidepressant drug fluoxetine (Fluox) with the metabolism of thyroid hormones (TH) in the rat, we applied our newly developed radiometric assays for iodothyronine deiodinases (IDs) of types 1, 2 and 3 (D1, D2 and D3, respectively), using [125I]-labeled iodothyronines of high specific radioactivity as substrates. We followed in details the effects of administration during 25 days to adult Wistar rats of Fluox alone or in combination with triiodothyronine (T-3) on the production and degradation of TH in the CNS and in different peripheral rat tissues. Surprisingly, administration of Fluox in combination with supraphysiological amounts of T-3 caused a distinctive fall of non-physiologically high concentrations of serum total T-3, which were reached by giving the animals the same amounts of T-3 alone, to nearly normal levels. Profound changes in IDs enzyme activities were determined, especially in the pituitary and cerebellum of treated rats. In conclusion, the elaborated radiometric assays for IDs were found to be usable for the assessment of changes in these enzyme activities, caused by the administration of the studied drugs to the rats.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

20305 - Nuclear related engineering; (nuclear physics to be 1.3);

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

RAD 2015: THE THIRD INTERNATIONAL CONFERENCE ON RADIATION AND APPLICATIONS IN VARIOUS FIELDS OF RESEARCH

ISBN

9788680300016

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

471-474

Název nakladatele

RAD ASSOC

Místo vydání

Serbia

Místo konání akce

Budva, MONTENEGRO

Datum konání akce

8. 6. 2015

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

000387979700098