EFFECTS OF FLUOXETINE ON THYROID HORMONES METABOLISM

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F15%3A00472836" target="_blank" >RIV/67985823:_____/15:00472836 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/15:00116082

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

EFFECTS OF FLUOXETINE ON THYROID HORMONES METABOLISM

Popis výsledku v původním jazyce

In studies of the interaction of an antidepressant drug fluoxetine (Fluox) with the metabolism of thyroid hormones (TH) in the rat, we applied our newly developed radiometric assays for iodothyronine deiodinases (IDs) of types 1, 2 and 3 (D1, D2 and D3, respectively), using [125I]-labeled iodothyronines of high specific radioactivity as substrates. We followed in details the effects of administration during 25 days to adult Wistar rats of Fluox alone or in combination with triiodothyronine (T3) on the production and degradation of TH in the CNS and in different peripheral rat tissues. Profound changes in IDs enzyme activities were determined, especially in the pituitary and cerebellum of treated rats. The elaborated radiometric assays for IDs were found to be usable for the assessment of changes in these enzyme activities, caused by the administration of the studied drugs to the rats.

Název v anglickém jazyce

EFFECTS OF FLUOXETINE ON THYROID HORMONES METABOLISM

Popis výsledku anglicky

In studies of the interaction of an antidepressant drug fluoxetine (Fluox) with the metabolism of thyroid hormones (TH) in the rat, we applied our newly developed radiometric assays for iodothyronine deiodinases (IDs) of types 1, 2 and 3 (D1, D2 and D3, respectively), using [125I]-labeled iodothyronines of high specific radioactivity as substrates. We followed in details the effects of administration during 25 days to adult Wistar rats of Fluox alone or in combination with triiodothyronine (T3) on the production and degradation of TH in the CNS and in different peripheral rat tissues. Profound changes in IDs enzyme activities were determined, especially in the pituitary and cerebellum of treated rats. The elaborated radiometric assays for IDs were found to be usable for the assessment of changes in these enzyme activities, caused by the administration of the studied drugs to the rats.

Druh

D - Stať ve sborníku

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

RAD 2015: THE THIRD INTERNATIONAL CONFERENCE ON RADIATION AND APPLICATIONS IN VARIOUS FIELDS OF RESEARCH

ISBN

978-86-80300-01-6

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

471-474

Název nakladatele

RAD ASSOC

Místo vydání

Niš

Místo konání akce

Budva

Datum konání akce

8. 6. 2015

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000387979700098