Association of genetic polymorphism with fat and bitter taste modalities in obese participants

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F16%3A00093960" target="_blank" >RIV/00216224:14310/16:00093960 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Association of genetic polymorphism with fat and bitter taste modalities in obese participants

Popis výsledku v původním jazyce

Orosensory perception of food strongly affects the ingestive behavior and intake of nutrients. The genetic variation in the genes encoding taste receptors also modulate the orosensory properties in human beings. The aim of this study was to evaluate the polymorphism in genes encoding bitter and lipid taste receptor in lean and obese subjects. We conducted our study on lean (n = 53) and obese (n = 53) participants that were recruited in National Institute of Nutrition (Tunis). We isolated the genomic DNA from the saliva swabs and, by employing restriction-fragment polymorphism (RFLP), we looked for the single nucleotide polymorphism (SNP) of two genes, CD36 (fat taste) and TAS2R38 (bitter taste). The CD36 gene variant was rs1761667 and TAS2R38 gene variants were rs1726866 and rs10246939. We noticed that A-genotype of rs1761667 was positively associated with obesity. Similarly, A-genotype and C-genotype, respectively of two rs1726866 and rs10246939 were associated with obesity.

Název v anglickém jazyce

Association of genetic polymorphism with fat and bitter taste modalities in obese participants

Popis výsledku anglicky

Orosensory perception of food strongly affects the ingestive behavior and intake of nutrients. The genetic variation in the genes encoding taste receptors also modulate the orosensory properties in human beings. The aim of this study was to evaluate the polymorphism in genes encoding bitter and lipid taste receptor in lean and obese subjects. We conducted our study on lean (n = 53) and obese (n = 53) participants that were recruited in National Institute of Nutrition (Tunis). We isolated the genomic DNA from the saliva swabs and, by employing restriction-fragment polymorphism (RFLP), we looked for the single nucleotide polymorphism (SNP) of two genes, CD36 (fat taste) and TAS2R38 (bitter taste). The CD36 gene variant was rs1761667 and TAS2R38 gene variants were rs1726866 and rs10246939. We noticed that A-genotype of rs1761667 was positively associated with obesity. Similarly, A-genotype and C-genotype, respectively of two rs1726866 and rs10246939 were associated with obesity.

Druh

O - Ostatní výsledky

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů