CD36 AA genotype is associated with decreased lipid taste perception in young obese, but not lean, children

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F15%3A00445123" target="_blank" >RIV/67985904:_____/15:00445123 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/15:00082609

Výsledek na webu

<a href="http://dx.doi.org/10.1038/ijo.2015.20" target="_blank" >http://dx.doi.org/10.1038/ijo.2015.20</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/ijo.2015.20" target="_blank" >10.1038/ijo.2015.20</a>

Jazyk výsledku

angličtina

Název v původním jazyce

CD36 AA genotype is associated with decreased lipid taste perception in young obese, but not lean, children

Popis výsledku v původním jazyce

Background/Objective: Obesity is an alarming threat for all age groups, including children. Fat overconsumption is one of the factors that directly influences this pathology. Recent studies have suggested that a common variant in the CD36 gene, that is, single-nucleotide polymorphism (SNP) rs1761667-A allele, that reduces CD36 expression, associates with high oral fat detection thresholds in some obese subjects. The objective was to assess fatty acid sensitivity in relation to CD36 SNP in young lean and obese children. Subjects/Methods: We studied lingual detection thresholds for emulsions, containing oleic acid, in Algerian children (n = 116, age = 80.5 years) who were divided into two groups: obese (n = 57; body mass index (BMI) z-score = 2.513 0.490) and lean children (n = 59; BMI z-score = -0.138 0.601) by alternative-forced choice method. To correlate the lipid taste perception thresholds with CD36 SNP, the children were genotyped for AG SNP rs1761667 in 5UTR region of CD36 by using PCR and restriction fragment length polymorphism. Results: We noticed significantly higher CD36 A-allele frequency (P = 0.036) in young obese children compared with leans. CD36 A-allele was associated with higher lipid taste perception thresholds than G-allele in obese children, but not in lean controls. Moreover, waist circumference was positively correlated with reduced fat taste sensitivity in these children. Conclusions: CD36 SNP A-allele, being present both in young lean and in obese children, is associated with high threshold for fatty acid taste sensitivity only in obese children.

Název v anglickém jazyce

CD36 AA genotype is associated with decreased lipid taste perception in young obese, but not lean, children

Popis výsledku anglicky

Background/Objective: Obesity is an alarming threat for all age groups, including children. Fat overconsumption is one of the factors that directly influences this pathology. Recent studies have suggested that a common variant in the CD36 gene, that is, single-nucleotide polymorphism (SNP) rs1761667-A allele, that reduces CD36 expression, associates with high oral fat detection thresholds in some obese subjects. The objective was to assess fatty acid sensitivity in relation to CD36 SNP in young lean and obese children. Subjects/Methods: We studied lingual detection thresholds for emulsions, containing oleic acid, in Algerian children (n = 116, age = 80.5 years) who were divided into two groups: obese (n = 57; body mass index (BMI) z-score = 2.513 0.490) and lean children (n = 59; BMI z-score = -0.138 0.601) by alternative-forced choice method. To correlate the lipid taste perception thresholds with CD36 SNP, the children were genotyped for AG SNP rs1761667 in 5UTR region of CD36 by using PCR and restriction fragment length polymorphism. Results: We noticed significantly higher CD36 A-allele frequency (P = 0.036) in young obese children compared with leans. CD36 A-allele was associated with higher lipid taste perception thresholds than G-allele in obese children, but not in lean controls. Moreover, waist circumference was positively correlated with reduced fat taste sensitivity in these children. Conclusions: CD36 SNP A-allele, being present both in young lean and in obese children, is associated with high threshold for fatty acid taste sensitivity only in obese children.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Obesity

ISSN

0307-0565

e-ISSN

—

Svazek periodika

39

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

920-924

Kód UT WoS článku

000356039500007

EID výsledku v databázi Scopus

2-s2.0-84930756224