Vaccine-driven evolution of parasite virulence and immune evasion in age-structured population: the case of pertussis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F16%3A00094238" target="_blank" >RIV/00216224:14310/16:00094238 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s12080-016-0300-5" target="_blank" >http://dx.doi.org/10.1007/s12080-016-0300-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12080-016-0300-5" target="_blank" >10.1007/s12080-016-0300-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Vaccine-driven evolution of parasite virulence and immune evasion in age-structured population: the case of pertussis

Popis výsledku v původním jazyce

Despite enormous success of mass immunization programs in reducing incidence of infectious diseases, vaccine-escape strains have emerged perhaps as a consequence of strong selection pressures exerted on parasites by vaccines. Pertussis presents a well-documented example. As a childhood infection, it exhibits age-specific transmission biased to children. Assuming different transmission rates between children and adults, I study, by means of an age-structured epidemic model, evolutionary dynamics of parasite virulence in a vaccinated population. I find that the age-structure does not affect the evolutionary dynamics of parasite virulence. Also, based on empirical data reporting antigenic divergence with vaccine strains and mutations in virulence-associated genes in pertussis populations, I allow for parallel occurrence of mutations in parasite virulence and associated immune evasion.

Název v anglickém jazyce

Vaccine-driven evolution of parasite virulence and immune evasion in age-structured population: the case of pertussis

Popis výsledku anglicky

Despite enormous success of mass immunization programs in reducing incidence of infectious diseases, vaccine-escape strains have emerged perhaps as a consequence of strong selection pressures exerted on parasites by vaccines. Pertussis presents a well-documented example. As a childhood infection, it exhibits age-specific transmission biased to children. Assuming different transmission rates between children and adults, I study, by means of an age-structured epidemic model, evolutionary dynamics of parasite virulence in a vaccinated population. I find that the age-structure does not affect the evolutionary dynamics of parasite virulence. Also, based on empirical data reporting antigenic divergence with vaccine strains and mutations in virulence-associated genes in pertussis populations, I allow for parallel occurrence of mutations in parasite virulence and associated immune evasion.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EH - Ekologie – společenstva

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Theoretical Ecology

ISSN

1874-1738

e-ISSN

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Svazek periodika

9

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

12

Strana od-do

431-442

Kód UT WoS článku

000388954400005

EID výsledku v databázi Scopus

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