Oil-based adjuvants delivered intradermally induce high primary IgG2 immune response in swine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F17%3A00111749" target="_blank" >RIV/00216224:14310/17:00111749 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00027162:_____/17:N0000016

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0034528817300474?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0034528817300474?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.rvsc.2017.03.007" target="_blank" >10.1016/j.rvsc.2017.03.007</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Oil-based adjuvants delivered intradermally induce high primary IgG2 immune response in swine

Popis výsledku v původním jazyce

The effects of intradermal application of antigen with or without different adjuvants and activation of immune response are presented in this study. Six groups of six piglets each were immunized with keyhole limpet haemocyanin (KLH) antigen in combination with aluminium hydroxide or oil-based adjuvants (complete and incomplete Freund's adjuvants, Montanide ISA 206 and Emulsigen). IgG1 and IgG2 levels in sera were measured by KLH-specific ELISA. Interestingly, oil-based adjuvants induced high primary IgG2 response, suggesting the Thl lymphocyte polarization. Also, considering the similarities between human and porcine organism, we suggest that intradermal application could be considered as an effective vaccine delivery route in both veterinary and human medicine.

Název v anglickém jazyce

Oil-based adjuvants delivered intradermally induce high primary IgG2 immune response in swine

Popis výsledku anglicky

The effects of intradermal application of antigen with or without different adjuvants and activation of immune response are presented in this study. Six groups of six piglets each were immunized with keyhole limpet haemocyanin (KLH) antigen in combination with aluminium hydroxide or oil-based adjuvants (complete and incomplete Freund's adjuvants, Montanide ISA 206 and Emulsigen). IgG1 and IgG2 levels in sera were measured by KLH-specific ELISA. Interestingly, oil-based adjuvants induced high primary IgG2 response, suggesting the Thl lymphocyte polarization. Also, considering the similarities between human and porcine organism, we suggest that intradermal application could be considered as an effective vaccine delivery route in both veterinary and human medicine.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

RESEARCH IN VETERINARY SCIENCE

ISSN

0034-5288

e-ISSN

1532-2661

Svazek periodika

114

Číslo periodika v rámci svazku

OCT

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

3

Strana od-do

41-43

Kód UT WoS článku

000414881800008

EID výsledku v databázi Scopus

2-s2.0-85015435515