Testing of N-alkoxyphenylhydronaphthalenecarboxamide activity against intestinal sulfate reducing bacteria

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Testing of N-alkoxyphenylhydronaphthalenecarboxamide activity against intestinal sulfate reducing bacteria

Popis výsledku v původním jazyce

The increased number of sulfate-reducing bacteria (SRB) and the intense process of dissimilatory sulfate reduction in the gut are thought to be significant risk factors of inflammatory bowel diseases in both humans and animals. These bacteria are often found in persons with rheumatic diseases, ankylosing spondylitis, etc. [1]. There is also an assumption that SRB can be responsible for some forms of cancer of the rectum through the formation of hydrogen sulfide that affects the metabolism of intestinal cells and give rise to various inflammatory bowel diseases [2,3]. Hydroxynaphthalene-2-carboxanilides can be considered as cyclic analogues of salicylanilides that have expressed promising results as potential antimicrobial agents. Their antimicrobial effects are connected with the ability of vicinal hydroxyarylamides to inhibit various enzymatic systems in bacteria. In addition, the presence of an amide group with a hydrophobic residue in its close vicinity is able, due to its electron properties, to interact and bind with a number of enzymes/receptors and affect the biological response by means of these target sites. The properties of the amide moiety can be easily modified by various substitutions [4,5]. In our previous research, antimicrobial effect of salicylamide derivatives against intestinal sulfatereducing bacteria as well as influence of selected 8-hydroxyquinoline-2-carboxanilides on viability and sulfate metabolism of Desulfovibrio piger were studied and described [6-7]. The present work is focused on investigation of the biological activity of N-alkoxyfenyl-3-hydroxynaftalen-2-carboxamides against intestinal sulfate-reducing bacteria isolated from mice.

Název v anglickém jazyce

Testing of N-alkoxyphenylhydronaphthalenecarboxamide activity against intestinal sulfate reducing bacteria

Popis výsledku anglicky

The increased number of sulfate-reducing bacteria (SRB) and the intense process of dissimilatory sulfate reduction in the gut are thought to be significant risk factors of inflammatory bowel diseases in both humans and animals. These bacteria are often found in persons with rheumatic diseases, ankylosing spondylitis, etc. [1]. There is also an assumption that SRB can be responsible for some forms of cancer of the rectum through the formation of hydrogen sulfide that affects the metabolism of intestinal cells and give rise to various inflammatory bowel diseases [2,3]. Hydroxynaphthalene-2-carboxanilides can be considered as cyclic analogues of salicylanilides that have expressed promising results as potential antimicrobial agents. Their antimicrobial effects are connected with the ability of vicinal hydroxyarylamides to inhibit various enzymatic systems in bacteria. In addition, the presence of an amide group with a hydrophobic residue in its close vicinity is able, due to its electron properties, to interact and bind with a number of enzymes/receptors and affect the biological response by means of these target sites. The properties of the amide moiety can be easily modified by various substitutions [4,5]. In our previous research, antimicrobial effect of salicylamide derivatives against intestinal sulfatereducing bacteria as well as influence of selected 8-hydroxyquinoline-2-carboxanilides on viability and sulfate metabolism of Desulfovibrio piger were studied and described [6-7]. The present work is focused on investigation of the biological activity of N-alkoxyfenyl-3-hydroxynaftalen-2-carboxamides against intestinal sulfate-reducing bacteria isolated from mice.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

10606 - Microbiology

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

SBORNÍK PŘÍSPĚVKŮ z výsledků řešení projektů IGA VFU Brno 2018 financovaných z prostředků účelové podpory na specifický vysokoškolský výzkum MŠMT na rok 2018

ISBN

9788073058111

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

176-179

Název nakladatele

VFU Brno

Místo vydání

BRNO

Místo konání akce

BRNO

Datum konání akce

1. 1. 2018

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

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