TiCaPCON-Supported Pt- and Fe-Based Nanoparticles and Related Antibacterial Activity
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F19%3A00110545" target="_blank" >RIV/00216224:14310/19:00110545 - isvavai.cz</a>
Výsledek na webu
<a href="https://pubs.acs.org/doi/abs/10.1021/acsami.9b09649" target="_blank" >https://pubs.acs.org/doi/abs/10.1021/acsami.9b09649</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsami.9b09649" target="_blank" >10.1021/acsami.9b09649</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
TiCaPCON-Supported Pt- and Fe-Based Nanoparticles and Related Antibacterial Activity
Popis výsledku v původním jazyce
A rapid increase in the number of antibiotic-resistant bacteria urgently requires the development of new more effective yet safe materials to fight infection. Herein, we uncovered the contribution of different metal nanoparticles (NPs) (Pt, Fe, and their combination) homogeneously distributed over the surface of nanostructured TiCaPCON films in the total antibacterial activity toward eight types of clinically isolated bacterial strains (Escherichia coli K261, Klebsiella pneumoniae B1079k/17-3, Acinetobacter baumannii B1280A/17, Staphylococcus aureus no. 839, Staphylococcus epidermidis i5189-1, Enterococcus faecium Ya-235: VanA, E. faecium I-237: VanA, and E. coli U20) taking into account various factors that can affect bacterial mechanisms: surface chemistry and phase composition, wettability, ion release, generation of reactive oxygen species (ROS), potential difference and polarity change between NPs and the surrounding matrix, formation of microgalvanic couples on the sample surfaces, and contribution of a passive oxide layer, formed on the surface of films, to general kinetics of the NP dissolution. The results indicated that metal ion implantation and subsequent annealing significantly changed the chemistry of the TiCaPCON film surface. This, in turn, greatly affected the shedding of ions, ROS formation, potential difference between film components, and antibacterial activity. The presence of NPs was critical for ROS generation under UV or daylight irradiation. By eliminating the potential contribution of ions and ROS, we have shown that bacteria can be killed using direct microgalvanic interactions. The possibility of charge redistribution at the interfaces between Pt NPs and TiO2 (anatase and rutile), TiC, TiN, and TiCN components was demonstrated using density functional theory calculations. The TiCaPCON-supported Pt and Fe NPs were not toxic for lymphocytes and had no effect on the ability of lymphocytes to activate in response to a mitogen. This study provides new insights into understanding and designing of antibacterial yet biologically safe surfaces.
Název v anglickém jazyce
TiCaPCON-Supported Pt- and Fe-Based Nanoparticles and Related Antibacterial Activity
Popis výsledku anglicky
A rapid increase in the number of antibiotic-resistant bacteria urgently requires the development of new more effective yet safe materials to fight infection. Herein, we uncovered the contribution of different metal nanoparticles (NPs) (Pt, Fe, and their combination) homogeneously distributed over the surface of nanostructured TiCaPCON films in the total antibacterial activity toward eight types of clinically isolated bacterial strains (Escherichia coli K261, Klebsiella pneumoniae B1079k/17-3, Acinetobacter baumannii B1280A/17, Staphylococcus aureus no. 839, Staphylococcus epidermidis i5189-1, Enterococcus faecium Ya-235: VanA, E. faecium I-237: VanA, and E. coli U20) taking into account various factors that can affect bacterial mechanisms: surface chemistry and phase composition, wettability, ion release, generation of reactive oxygen species (ROS), potential difference and polarity change between NPs and the surrounding matrix, formation of microgalvanic couples on the sample surfaces, and contribution of a passive oxide layer, formed on the surface of films, to general kinetics of the NP dissolution. The results indicated that metal ion implantation and subsequent annealing significantly changed the chemistry of the TiCaPCON film surface. This, in turn, greatly affected the shedding of ions, ROS formation, potential difference between film components, and antibacterial activity. The presence of NPs was critical for ROS generation under UV or daylight irradiation. By eliminating the potential contribution of ions and ROS, we have shown that bacteria can be killed using direct microgalvanic interactions. The possibility of charge redistribution at the interfaces between Pt NPs and TiO2 (anatase and rutile), TiC, TiN, and TiCN components was demonstrated using density functional theory calculations. The TiCaPCON-supported Pt and Fe NPs were not toxic for lymphocytes and had no effect on the ability of lymphocytes to activate in response to a mitogen. This study provides new insights into understanding and designing of antibacterial yet biologically safe surfaces.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
21001 - Nano-materials (production and properties)
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
ACS Applied Materials & Interfaces
ISSN
1944-8244
e-ISSN
1944-8252
Svazek periodika
11
Číslo periodika v rámci svazku
32
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
21
Strana od-do
28699-28719
Kód UT WoS článku
000481567100012
EID výsledku v databázi Scopus
2-s2.0-85070892341