Microstructure, chemical and biological performance of boron-modified TiCaPCON films

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F19%3APU130330" target="_blank" >RIV/00216305:26620/19:PU130330 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S016943321832573X" target="_blank" >https://www.sciencedirect.com/science/article/pii/S016943321832573X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apsusc.2018.09.157" target="_blank" >10.1016/j.apsusc.2018.09.157</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microstructure, chemical and biological performance of boron-modified TiCaPCON films

Popis výsledku v původním jazyce

The fabrication of biologically safe materials with enhanced antibacterial characteristics is of great significance. Here we propose B-based therapeutic strategy which offers a good alternative to the widely used approach based on the introduction of most famous bactericidal elements, such as Ag, Cu, and Zn. B-doped TiCaPCON films with 8, 11, and 15 at.% of B were obtained by simultaneous magnetron sputtering of two composite targets (TiC-CaOTi3POx and TiB2) in a gaseous mixture of Ar+15%N2. The B content in the films was controlled by changing magnetron current of the TiB2 target. The B-doped films were thoroughly studied by means of scanning and transmission electron microscopy, high-resolution TEM, X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and glow discharge optical emission spectroscopy. The films were also characterized with respect to surface wettability, boron ion release, and electrochemical characteristics. To test biocompatibility and bioactivity of the films in vitro, spreading, actin cytoskeleton organization, proliferation and osteogenic differentiation of MC3T3-E1 osteoblastic cells grown on the film surface were studied. The antibacterial characteristics of the B-doped TiCaPCON samples against antibiotic- resistant Escherichia coli (E. coli) 261 strains were compared with two-layer BOx/TiCaPCON–B and TiOx/ TiCaPCON–B films obtained by three different methods: (i) deposition of a B2O3 top layer, (ii) annealing and (iii) electrochemical oxidation of the as-deposited B-doped films. The obtained results clearly indicated that all types of B-containing films are not toxic for cells regardless of their surface composition. Antibacterial activity tests revealed that only the sample with B2O3 top layer completely inactivated E. coli cells and prevented biofilm formation. Thus the surface of two-layer B2O3/TiCaPCON–11%B film was simultaneously bactericidal towards E. coli strains and not-t

Název v anglickém jazyce

Microstructure, chemical and biological performance of boron-modified TiCaPCON films

Popis výsledku anglicky

The fabrication of biologically safe materials with enhanced antibacterial characteristics is of great significance. Here we propose B-based therapeutic strategy which offers a good alternative to the widely used approach based on the introduction of most famous bactericidal elements, such as Ag, Cu, and Zn. B-doped TiCaPCON films with 8, 11, and 15 at.% of B were obtained by simultaneous magnetron sputtering of two composite targets (TiC-CaOTi3POx and TiB2) in a gaseous mixture of Ar+15%N2. The B content in the films was controlled by changing magnetron current of the TiB2 target. The B-doped films were thoroughly studied by means of scanning and transmission electron microscopy, high-resolution TEM, X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and glow discharge optical emission spectroscopy. The films were also characterized with respect to surface wettability, boron ion release, and electrochemical characteristics. To test biocompatibility and bioactivity of the films in vitro, spreading, actin cytoskeleton organization, proliferation and osteogenic differentiation of MC3T3-E1 osteoblastic cells grown on the film surface were studied. The antibacterial characteristics of the B-doped TiCaPCON samples against antibiotic- resistant Escherichia coli (E. coli) 261 strains were compared with two-layer BOx/TiCaPCON–B and TiOx/ TiCaPCON–B films obtained by three different methods: (i) deposition of a B2O3 top layer, (ii) annealing and (iii) electrochemical oxidation of the as-deposited B-doped films. The obtained results clearly indicated that all types of B-containing films are not toxic for cells regardless of their surface composition. Antibacterial activity tests revealed that only the sample with B2O3 top layer completely inactivated E. coli cells and prevented biofilm formation. Thus the surface of two-layer B2O3/TiCaPCON–11%B film was simultaneously bactericidal towards E. coli strains and not-t

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Applied Surface Science

ISSN

0169-4332

e-ISSN

1873-5584

Svazek periodika

465

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

486-497

Kód UT WoS článku

000449683100056

EID výsledku v databázi Scopus

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