Anti-alpha gal antibodies in the context of blood group and stool and tumour-adjacent microbiome in colorectal cancer patients

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F19%3A00113691" target="_blank" >RIV/00216224:14310/19:00113691 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.annalsofoncology.org/article/S0923-7534(20)34474-4/pdf" target="_blank" >https://www.annalsofoncology.org/article/S0923-7534(20)34474-4/pdf</a>
DOI - Digital Object Identifier
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Jazyk výsledku
angličtina
Název v původním jazyce
Anti-alpha gal antibodies in the context of blood group and stool and tumour-adjacent microbiome in colorectal cancer patients
Popis výsledku v původním jazyce
Gut microbiome plays a role in the development and clinical course of colorectal cancer (CRC). Natural antibodies against galactose-a-1,3-galactose (a-gal) are highly abundant in humans due to regular stimulation from gut bacteria. Similarly, Abs against AB0 blood group antigens are produced as cross-reacting with intestinal bacteria and a-gal epitope has similar structure to blood group B Ag. Blood group antigens may be associated with an expansion families of gut bacteria.
Název v anglickém jazyce
Anti-alpha gal antibodies in the context of blood group and stool and tumour-adjacent microbiome in colorectal cancer patients
Popis výsledku anglicky
Gut microbiome plays a role in the development and clinical course of colorectal cancer (CRC). Natural antibodies against galactose-a-1,3-galactose (a-gal) are highly abundant in humans due to regular stimulation from gut bacteria. Similarly, Abs against AB0 blood group antigens are produced as cross-reacting with intestinal bacteria and a-gal epitope has similar structure to blood group B Ag. Blood group antigens may be associated with an expansion families of gut bacteria.

Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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