bHLH heterodimer complex variations regulate cell proliferation activity in the meristems of Arabidopsis thaliana

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F22%3A00126912" target="_blank" >RIV/00216224:14310/22:00126912 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.cell.com/iscience/fulltext/S2589-0042(22)01636-4" target="_blank" >https://www.cell.com/iscience/fulltext/S2589-0042(22)01636-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.isci.2022.105364" target="_blank" >10.1016/j.isci.2022.105364</a>

Jazyk výsledku

angličtina

Název v původním jazyce

bHLH heterodimer complex variations regulate cell proliferation activity in the meristems of Arabidopsis thaliana

Popis výsledku v původním jazyce

Root, shoot and lateral meristems are the main regions of cell proliferation in plants. It has been proposed that meristems might have evolved dedicated transcriptional networks to balance cell proliferation. Here, we show that basic Helix Loop Helix (bHLH) transcription factor heterodimers formed by members of the TARGET OF MONOPTEROS5 (TMO5) and LONESOME HIGHWAY (LHW) subclades are general regulators of cell proliferation in all meristems. Yet, genetics and expression analyses suggest specific functions of these transcription factors in distinct meristems, possibly due to their expression domains determining heterodimer complex variations within meristems, and to a certain extent to the absence of some of them in a given meristem. Target gene specificity analysis for heterodimer complexes focusing on the LONELY GUY gene targets further suggests differences in transcriptional responses through heterodimer diversification that could allow a common bHLH heterodimer complex module to contribute to cell proliferation control in multiple meristems.

Název v anglickém jazyce

bHLH heterodimer complex variations regulate cell proliferation activity in the meristems of Arabidopsis thaliana

Popis výsledku anglicky

Root, shoot and lateral meristems are the main regions of cell proliferation in plants. It has been proposed that meristems might have evolved dedicated transcriptional networks to balance cell proliferation. Here, we show that basic Helix Loop Helix (bHLH) transcription factor heterodimers formed by members of the TARGET OF MONOPTEROS5 (TMO5) and LONESOME HIGHWAY (LHW) subclades are general regulators of cell proliferation in all meristems. Yet, genetics and expression analyses suggest specific functions of these transcription factors in distinct meristems, possibly due to their expression domains determining heterodimer complex variations within meristems, and to a certain extent to the absence of some of them in a given meristem. Target gene specificity analysis for heterodimer complexes focusing on the LONELY GUY gene targets further suggests differences in transcriptional responses through heterodimer diversification that could allow a common bHLH heterodimer complex module to contribute to cell proliferation control in multiple meristems.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10600 - Biological sciences

Projekt

<a href="/cs/project/EF17_050%2F0008496" target="_blank" >EF17_050/0008496: MSCAfellow@MUNI</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ISCIENCE

ISSN

2589-0042

e-ISSN

2589-0042

Svazek periodika

25

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

19

Strana od-do

105364

Kód UT WoS článku

000964036200006

EID výsledku v databázi Scopus

2-s2.0-85140805385