bHLH heterodimer complex variations regulate cell proliferation activity in Arabidopsis thaliana meristems

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F23%3A00131419" target="_blank" >RIV/00216224:14310/23:00131419 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.acpd2023.org/" target="_blank" >https://www.acpd2023.org/</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

bHLH heterodimer complex variations regulate cell proliferation activity in Arabidopsis thaliana meristems

Popis výsledku v původním jazyce

Root, shoot, and lateral meristems are the main regions of cell proliferation in plants. It has been proposed that meristems might have evolved dedicated transcriptional networks for cell proliferation homeostasis. Here, we show that basic helix-loop-helix (bHLH) transcription factor heterodimers formed between members of the TARGET OF MONOPTEROS5 (TMO5) and the LONESOME HIGHWAY (LHW) subclades are general regulators of cell proliferation in all meristems. Yet, genetics and expression analyses suggest specific functions of these transcription factors in distinct meristems, possibly due to their expression domains determining heterodimer complex variations within meristems, and to a certain extent, to some of them being absent in a given meristem. Target gene specificity analysis for heterodimer complexes focusing on LONELY GUY gene targets further suggests differences in transcriptional responses through heterodimer diversification that could allow a common bHLH heterodimer complex module to contribute to cell proliferation control in multiple meristems.

Název v anglickém jazyce

bHLH heterodimer complex variations regulate cell proliferation activity in Arabidopsis thaliana meristems

Popis výsledku anglicky

Root, shoot, and lateral meristems are the main regions of cell proliferation in plants. It has been proposed that meristems might have evolved dedicated transcriptional networks for cell proliferation homeostasis. Here, we show that basic helix-loop-helix (bHLH) transcription factor heterodimers formed between members of the TARGET OF MONOPTEROS5 (TMO5) and the LONESOME HIGHWAY (LHW) subclades are general regulators of cell proliferation in all meristems. Yet, genetics and expression analyses suggest specific functions of these transcription factors in distinct meristems, possibly due to their expression domains determining heterodimer complex variations within meristems, and to a certain extent, to some of them being absent in a given meristem. Target gene specificity analysis for heterodimer complexes focusing on LONELY GUY gene targets further suggests differences in transcriptional responses through heterodimer diversification that could allow a common bHLH heterodimer complex module to contribute to cell proliferation control in multiple meristems.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10600 - Biological sciences

Projekt

<a href="/cs/project/EF17_050%2F0008496" target="_blank" >EF17_050/0008496: MSCAfellow@MUNI</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů