Biomimetic antimicrobial polymers-Design, characterization, antimicrobial, and novel applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F23%3A00133002" target="_blank" >RIV/00216224:14310/23:00133002 - isvavai.cz</a>

Výsledek na webu

<a href="https://wires.onlinelibrary.wiley.com/doi/10.1002/wnan.1866" target="_blank" >https://wires.onlinelibrary.wiley.com/doi/10.1002/wnan.1866</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/wnan.1866" target="_blank" >10.1002/wnan.1866</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biomimetic antimicrobial polymers-Design, characterization, antimicrobial, and novel applications

Popis výsledku v původním jazyce

Biomimetic antimicrobial polymers have been an area of great interest as the need for novel antimicrobial compounds grows due to the development of resistance. These polymers were designed and developed to mimic naturally occurring antimicrobial peptides in both physicochemical composition and mechanism of action. These antimicrobial peptide mimetic polymers have been extensively investigated using chemical, biophysical, microbiological, and computational approaches to gain a deeper understanding of the molecular interactions that drive function. These studies have helped inform SARs, mechanism of action, and general physicochemical factors that influence the activity and properties of antimicrobial polymers. However, there are still lingering questions in this field regarding 3D structural patterning, bioavailability, and applicability to alternative targets. In this review, we present a perspective on the development and characterization of several antimicrobial polymers and discuss novel applications of these molecules emerging in the field. This article is categorized under: Therapeutic Approaches and Drug Discovery &gt; Emerging Technologies Therapeutic Approaches and Drug Discovery &gt; Nanomedicine for Infectious Disease

Název v anglickém jazyce

Biomimetic antimicrobial polymers-Design, characterization, antimicrobial, and novel applications

Popis výsledku anglicky

Biomimetic antimicrobial polymers have been an area of great interest as the need for novel antimicrobial compounds grows due to the development of resistance. These polymers were designed and developed to mimic naturally occurring antimicrobial peptides in both physicochemical composition and mechanism of action. These antimicrobial peptide mimetic polymers have been extensively investigated using chemical, biophysical, microbiological, and computational approaches to gain a deeper understanding of the molecular interactions that drive function. These studies have helped inform SARs, mechanism of action, and general physicochemical factors that influence the activity and properties of antimicrobial polymers. However, there are still lingering questions in this field regarding 3D structural patterning, bioavailability, and applicability to alternative targets. In this review, we present a perspective on the development and characterization of several antimicrobial polymers and discuss novel applications of these molecules emerging in the field. This article is categorized under: Therapeutic Approaches and Drug Discovery &gt; Emerging Technologies Therapeutic Approaches and Drug Discovery &gt; Nanomedicine for Infectious Disease

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21000 - Nano-technology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY

ISSN

1939-5116

e-ISSN

—

Svazek periodika

15

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

33

Strana od-do

1-33

Kód UT WoS článku

000877238100001

EID výsledku v databázi Scopus

2-s2.0-85141347878