Role of sigma signalling in mammalian myocardium

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F03%3A00009084" target="_blank" >RIV/00216224:14330/03:00009084 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Role of sigma signalling in mammalian myocardium

Popis výsledku v původním jazyce

Sigma receptors represent a group of enigmatic binding sites with many functions in different tissues. In rat heart, they are responsible for modulation of cardiac contractility. They are also responsible for some adverse side effects of certain psychotropic drugs on cardiovascular system. In this study, the effect of sigma receptor ligand haloperidol on guinea pig heart multicellular preparations was studied. Its positive inotropic effect previously described in rat cardiomyocytes was confirmed in leftatria and papillary muscles isolated from the right ventricles. Also desensitisation process previously reported in rat myocardium after repeated exposure to haloperidol was confirmed. The normalized course of mechanical restitution curve was not changed during perfusion with haloperidol. It is concluded that its positive inotropic effect is very likely mediated via increased cytosolic availability of calcium.

Název v anglickém jazyce

Role of sigma signalling in mammalian myocardium

Popis výsledku anglicky

Sigma receptors represent a group of enigmatic binding sites with many functions in different tissues. In rat heart, they are responsible for modulation of cardiac contractility. They are also responsible for some adverse side effects of certain psychotropic drugs on cardiovascular system. In this study, the effect of sigma receptor ligand haloperidol on guinea pig heart multicellular preparations was studied. Its positive inotropic effect previously described in rat cardiomyocytes was confirmed in leftatria and papillary muscles isolated from the right ventricles. Also desensitisation process previously reported in rat myocardium after repeated exposure to haloperidol was confirmed. The normalized course of mechanical restitution curve was not changed during perfusion with haloperidol. It is concluded that its positive inotropic effect is very likely mediated via increased cytosolic availability of calcium.

Druh

D - Stať ve sborníku

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Chronobiological analysis in pathophysiology of cardiovascular system

ISBN

80-7013-394-5

ISSN

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e-ISSN

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Počet stran výsledku

7

Strana od-do

172

Název nakladatele

National Centre of Nursing and Other Health Professions and Masaryk University, Faculty of Medicine

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

1. 1. 2003

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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