Účinek ligandu sigma receptoru haloperidolu na srdce morčete
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F04%3A00011533" target="_blank" >RIV/00216224:14110/04:00011533 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Effect of Sigma Receptor Ligand Haloperidol in Guinea Pig Heart
Popis výsledku v původním jazyce
Sigma receptors represent a group of enigmatic binding sites with many functions in different tissues. In rat heart, they are responsible for modulation of cardiac contractility. They are also responsible for some adverse side effects of certain psychotropic drugs on cardiovascular system. In this study, the effect of sigma receptor ligand haloperidol on guinea pig heart multicellular preparations was studied. Its positive inotropic effect previously described in rat cardiomyocytes was confirmed in leftatria and papillary muscles isolated from the right ventricles (an increase of the twitch amplitude by 36% to 123% in comparison with the control period in atria and by 9% to 46% in ventricular preparations; all values were statistically significant when compared to control in atrial preparations, but only in the first five min of perfusion in papillary muscles). Also desensitisation process previously reported in rat myocardium after repeated exposure to haloperidol was confirmed (alth
Název v anglickém jazyce
Effect of Sigma Receptor Ligand Haloperidol in Guinea Pig Heart
Popis výsledku anglicky
Sigma receptors represent a group of enigmatic binding sites with many functions in different tissues. In rat heart, they are responsible for modulation of cardiac contractility. They are also responsible for some adverse side effects of certain psychotropic drugs on cardiovascular system. In this study, the effect of sigma receptor ligand haloperidol on guinea pig heart multicellular preparations was studied. Its positive inotropic effect previously described in rat cardiomyocytes was confirmed in leftatria and papillary muscles isolated from the right ventricles (an increase of the twitch amplitude by 36% to 123% in comparison with the control period in atria and by 9% to 46% in ventricular preparations; all values were statistically significant when compared to control in atrial preparations, but only in the first five min of perfusion in papillary muscles). Also desensitisation process previously reported in rat myocardium after repeated exposure to haloperidol was confirmed (alth
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
ED - Fyziologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GA305%2F04%2F1385" target="_blank" >GA305/04/1385: Modulační úloha sigma signalizace na elektromechanické vztahy izolovaného kardiomyocytu a srdce</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2004
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Acta Veterinaria Brunensis
ISSN
0001-7213
e-ISSN
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Svazek periodika
73
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
8
Strana od-do
313-320
Kód UT WoS článku
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EID výsledku v databázi Scopus
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