In silico search for secondary structures in p53 target genes using R/Bioconductor

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F13%3A00068953" target="_blank" >RIV/00216224:14330/13:00068953 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.researchgate.net/publication/254257375_In_silico_search_for_secondary_structures_in_p53_target_genes_using_RBioconductor?ev=prf_pub" target="_blank" >https://www.researchgate.net/publication/254257375_In_silico_search_for_secondary_structures_in_p53_target_genes_using_RBioconductor?ev=prf_pub</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

In silico search for secondary structures in p53 target genes using R/Bioconductor

Popis výsledku v původním jazyce

p53 is a well-known transcription factor and tumor suppressor, regulating among other processes, the commitment of cells to apoptosis and DNA repair. p53 mutants are often found in cancers of different kinds, ei- ther as mutant or misregulated p53. p53 is involved in many other processes and we currently do not understand the full range of its functions. It is known to recognize the p53con sequence by its specific DNA-binding domain (DBD). It is also known to bind DNA non-specifically. This binding hasbeen shown to involve superhelical DNA, more specifically, cruciform, triplex and quadruplex struc- tures. In our laboratories we were intrigued by the possi- ble interplay between non-canonical DNA structure bind- ing and regular p53con binding. In an attempt to clarify this interplay and discover suitable candidate genes for fur- ther study, we carried out an in silico study on the human genome.

Název v anglickém jazyce

In silico search for secondary structures in p53 target genes using R/Bioconductor

Popis výsledku anglicky

p53 is a well-known transcription factor and tumor suppressor, regulating among other processes, the commitment of cells to apoptosis and DNA repair. p53 mutants are often found in cancers of different kinds, ei- ther as mutant or misregulated p53. p53 is involved in many other processes and we currently do not understand the full range of its functions. It is known to recognize the p53con sequence by its specific DNA-binding domain (DBD). It is also known to bind DNA non-specifically. This binding hasbeen shown to involve superhelical DNA, more specifically, cruciform, triplex and quadruplex struc- tures. In our laboratories we were intrigued by the possi- ble interplay between non-canonical DNA structure bind- ing and regular p53con binding. In an attempt to clarify this interplay and discover suitable candidate genes for fur- ther study, we carried out an in silico study on the human genome.

Druh

D - Stať ve sborníku

CEP obor

IN - Informatika

OECD FORD obor

—

Projekt

<a href="/cs/project/LG13010" target="_blank" >LG13010: Zastoupení ČR v European Research Consortium for Informatics and Mathematics</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

ITAT 2013: Information Technologies - Applications and Theory (Workshops, Posters, and Tutorials)

ISBN

149095208X

ISSN

—

e-ISSN

—

Počet stran výsledku

5

Strana od-do

42-46

Název nakladatele

CreateSpace Independent Publishing Platform

Místo vydání

Neuvedeno

Místo konání akce

Donovaly, SVK

Datum konání akce

11. 9. 2013

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

—