Detection of Intramolecular Tunnels Connecting Sequence of Sites in Protein Structures

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F14%3A00074781" target="_blank" >RIV/00216224:14330/14:00074781 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-3-319-07581-5_9" target="_blank" >http://dx.doi.org/10.1007/978-3-319-07581-5_9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-319-07581-5_9" target="_blank" >10.1007/978-3-319-07581-5_9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Detection of Intramolecular Tunnels Connecting Sequence of Sites in Protein Structures

Popis výsledku v původním jazyce

Proteins are essential for functioning of all living organisms and studying their inner structure and functions has been of a high importance. Many studies concentrated on detection of various inner structures inside macromolecules (e.g. tunnels, channels, pores) which play an essential role in the functioning of a large number of proteins. Here we present a novel approach to a detection of intramolecular tunnels. These pathways may facilitate the transport of reaction intermediates among buried activesites. The results obtained by the proposed algorithm were compared to intramolecular tunnels whose presence in given structures is already known. The algorithm is able to also identify other inner structures, such as channels or pores.

Název v anglickém jazyce

Detection of Intramolecular Tunnels Connecting Sequence of Sites in Protein Structures

Popis výsledku anglicky

Proteins are essential for functioning of all living organisms and studying their inner structure and functions has been of a high importance. Many studies concentrated on detection of various inner structures inside macromolecules (e.g. tunnels, channels, pores) which play an essential role in the functioning of a large number of proteins. Here we present a novel approach to a detection of intramolecular tunnels. These pathways may facilitate the transport of reaction intermediates among buried activesites. The results obtained by the proposed algorithm were compared to intramolecular tunnels whose presence in given structures is already known. The algorithm is able to also identify other inner structures, such as channels or pores.

Druh

D - Stať ve sborníku

CEP obor

IN - Informatika

OECD FORD obor

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Projekt

<a href="/cs/project/LG13010" target="_blank" >LG13010: Zastoupení ČR v European Research Consortium for Informatics and Mathematics</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Advances in Intelligent Systems and Computing

ISBN

9783319075808

ISSN

2194-5357

e-ISSN

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Počet stran výsledku

8

Strana od-do

73-80

Název nakladatele

Springer International Publishing

Místo vydání

Switzerland

Místo konání akce

Casablanca

Datum konání akce

1. 1. 2014

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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