Uneven distribution of potential triplex sequences in the human genome. In silico study using the R/Bioconductor package triplex.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F14%3A00074890" target="_blank" >RIV/00216224:14330/14:00074890 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26230/14:PU111943

Výsledek na webu

<a href="http://dx.doi.org/10.5220/0004824100800088" target="_blank" >http://dx.doi.org/10.5220/0004824100800088</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5220/0004824100800088" target="_blank" >10.5220/0004824100800088</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Uneven distribution of potential triplex sequences in the human genome. In silico study using the R/Bioconductor package triplex.

Popis výsledku v původním jazyce

Eukaryotic genomes are rich in sequences capable of forming non-B DNA structures. These structures are expected to play important roles in natural regulatory processes at levels above those of individual genes, such as whole genome dynamics or chromatinorganization, as well as in processes leading to the loss of these functions, such as cancer development. Recently, a number of authors have mapped the occurrence of potential quadruplex sequences in the human genome and found them to be associated withpromoters. In this paper, we set out to map the distribution and characteristics of potential triplex-forming sequences in human genome DNA sequences. Using the R/Bioconductor package {it triplex}, we found these sequences to be excluded from exons, while present mostly in a small number of repetitive sequence classes, especially short sequence tandem repeats (microsatellites), Alu and combined elements, such as SVA.

Název v anglickém jazyce

Uneven distribution of potential triplex sequences in the human genome. In silico study using the R/Bioconductor package triplex.

Popis výsledku anglicky

Eukaryotic genomes are rich in sequences capable of forming non-B DNA structures. These structures are expected to play important roles in natural regulatory processes at levels above those of individual genes, such as whole genome dynamics or chromatinorganization, as well as in processes leading to the loss of these functions, such as cancer development. Recently, a number of authors have mapped the occurrence of potential quadruplex sequences in the human genome and found them to be associated withpromoters. In this paper, we set out to map the distribution and characteristics of potential triplex-forming sequences in human genome DNA sequences. Using the R/Bioconductor package {it triplex}, we found these sequences to be excluded from exons, while present mostly in a small number of repetitive sequence classes, especially short sequence tandem repeats (microsatellites), Alu and combined elements, such as SVA.

Druh

D - Stať ve sborníku

CEP obor

IN - Informatika

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms

ISBN

9789897580123

ISSN

—

e-ISSN

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Počet stran výsledku

9

Strana od-do

80-88

Název nakladatele

SciTePress

Místo vydání

Angers, France

Místo konání akce

Angers, FR

Datum konání akce

3. 3. 2014

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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