Biodistribution of non-coated gamma-Fe2O3 nanoparticles in stem cells
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F15%3A00081086" target="_blank" >RIV/00216224:14330/15:00081086 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Biodistribution of non-coated gamma-Fe2O3 nanoparticles in stem cells
Popis výsledku v původním jazyce
Superparamagnetic iron oxide nanoparticles have become a useful tool in biomedicine. Their applications include cell labelling for magnetic resonance imaging, drug and gene delivery and cell targeting. Targeting cells to a specific location is a first step in development of regenerative cellular therapy. To provide optimal dispersion, increase nanoparticle intake and minimize toxic effects Fe2O3 nanoparticles are often coated with different types of organic materials including citrate, dextran, albumin,starch polyethylene glycol or dimercaptosuccinic acid. However, magnetism of the nanoparticles decreases with diameter of the coating. Recently, the gamma-Fe2O3 nanoparticles were synthesized in gas phase by microwave plasma torch without any surfactants and additives. Therefore, this technology can open new perspectives for bioapplications. We studied interaction of different cell cultures including pluripotent cells with microwave-torch gamma-e2O3 nanoparticles.
Název v anglickém jazyce
Biodistribution of non-coated gamma-Fe2O3 nanoparticles in stem cells
Popis výsledku anglicky
Superparamagnetic iron oxide nanoparticles have become a useful tool in biomedicine. Their applications include cell labelling for magnetic resonance imaging, drug and gene delivery and cell targeting. Targeting cells to a specific location is a first step in development of regenerative cellular therapy. To provide optimal dispersion, increase nanoparticle intake and minimize toxic effects Fe2O3 nanoparticles are often coated with different types of organic materials including citrate, dextran, albumin,starch polyethylene glycol or dimercaptosuccinic acid. However, magnetism of the nanoparticles decreases with diameter of the coating. Recently, the gamma-Fe2O3 nanoparticles were synthesized in gas phase by microwave plasma torch without any surfactants and additives. Therefore, this technology can open new perspectives for bioapplications. We studied interaction of different cell cultures including pluripotent cells with microwave-torch gamma-e2O3 nanoparticles.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
EA - Morfologické obory a cytologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GBP302%2F12%2FG157" target="_blank" >GBP302/12/G157: Dynamika a organizace chromosomů během buněčného cyklu a při diferenciaci v normě a patologii</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů