Paramagnetic nanoparticles in stem cell therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F16%3A00088444" target="_blank" >RIV/00216224:14330/16:00088444 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Paramagnetic nanoparticles in stem cell therapy

Popis výsledku v původním jazyce

In recent years metal oxide nanoparticles have become a useful tool in biomedicine. They are used as contrast agents for magnetic resonance imaging, carriers in drug delivery, compounds for hyperthermia cancer treatment or targets for cell tracking and guiding mechanisms. Even though recent advances bring stem cell therapy closer to clinical application, several issues must be addressed. The success of the healing process depends on precision targeting into the site of the injury. Nanoparticles provide a mechanism that effectively guides cells to the site of the action. Recently gamma–Fe2O3 and Fe3O4 were synthetized by microwave plasma torch. We studied the interaction and endocytosis of the nanoparticles with various cell cultures in order to optimize the process for future clinical application. We focused on cells with different stem properties, including human neonatal fibroblasts, human umbilical vein endothelial cells, adult vein endothelial cells and pluripotent stem cells.

Název v anglickém jazyce

Paramagnetic nanoparticles in stem cell therapy

Popis výsledku anglicky

In recent years metal oxide nanoparticles have become a useful tool in biomedicine. They are used as contrast agents for magnetic resonance imaging, carriers in drug delivery, compounds for hyperthermia cancer treatment or targets for cell tracking and guiding mechanisms. Even though recent advances bring stem cell therapy closer to clinical application, several issues must be addressed. The success of the healing process depends on precision targeting into the site of the injury. Nanoparticles provide a mechanism that effectively guides cells to the site of the action. Recently gamma–Fe2O3 and Fe3O4 were synthetized by microwave plasma torch. We studied the interaction and endocytosis of the nanoparticles with various cell cultures in order to optimize the process for future clinical application. We focused on cells with different stem properties, including human neonatal fibroblasts, human umbilical vein endothelial cells, adult vein endothelial cells and pluripotent stem cells.

Druh

O - Ostatní výsledky

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GBP302%2F12%2FG157" target="_blank" >GBP302/12/G157: Dynamika a organizace chromosomů během buněčného cyklu a při diferenciaci v normě a patologii</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů