Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F11%3A00053053" target="_blank" >RIV/00216224:14740/11:00053053 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.neulet.2011.06.052" target="_blank" >http://dx.doi.org/10.1016/j.neulet.2011.06.052</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neulet.2011.06.052" target="_blank" >10.1016/j.neulet.2011.06.052</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve

Popis výsledku v původním jazyce

Interleukin-10 prevents transition of a physiological inflammatory reaction to a pathological state that may result in neuropathic pain. We studied bilateral changes of IL-10 in L4?L5 and C7?C8 dorsal root ganglia (DRG) after a chronic constriction injury (CCI) of spinal nerves or the sciatic nerve. Rats were left to survive for 1,3,7 or 14d, sham-operated for 3 or 14 d. IL-10 was detected by immunohistochemical staining and measured using ELISA analysis. Unilateral CCI induced a transient bilateral elevation in IL-10 not only in the homonymous lumbar but also in the heteronymous cervical DRG. Sham operations also induced bilateral elevation of IL-10 in both homonymous and heteronymous DRG. Our experiments revealed that the more proximal is a nerve injury the more rapid is the initial increase and slower the subsequent decrease of IL-10 in DRG.

Název v anglickém jazyce

Bilateral changes of IL-10 protein in lumbar and cervical dorsal root ganglia following proximal and distal chronic constriction injury of peripheral nerve

Popis výsledku anglicky

Interleukin-10 prevents transition of a physiological inflammatory reaction to a pathological state that may result in neuropathic pain. We studied bilateral changes of IL-10 in L4?L5 and C7?C8 dorsal root ganglia (DRG) after a chronic constriction injury (CCI) of spinal nerves or the sciatic nerve. Rats were left to survive for 1,3,7 or 14d, sham-operated for 3 or 14 d. IL-10 was detected by immunohistochemical staining and measured using ELISA analysis. Unilateral CCI induced a transient bilateral elevation in IL-10 not only in the homonymous lumbar but also in the heteronymous cervical DRG. Sham operations also induced bilateral elevation of IL-10 in both homonymous and heteronymous DRG. Our experiments revealed that the more proximal is a nerve injury the more rapid is the initial increase and slower the subsequent decrease of IL-10 in DRG.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroscience Letters

ISSN

0304-3940

e-ISSN

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Svazek periodika

501

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

6

Strana od-do

86-91

Kód UT WoS článku

000294317600006

EID výsledku v databázi Scopus

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