MicroRNAs Biogenesis, Function and Decay

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00060169" target="_blank" >RIV/00216224:14740/12:00060169 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

MicroRNAs Biogenesis, Function and Decay

Popis výsledku v původním jazyce

MicroRNAs (miRNAs) are important regulators of gene expression that control both physiological and pathological processes such as development and cancer. Research during the past decade has identified major factors participating in miRNA biogenesis and has established basic principles of miRNA function. Recent studies, however, have introduced a paradigm shift in our understanding of the miRNA biogenesis pathway, which was previously believed to be universal to all miRNAs. It has become apparent that miRNA regulators themselves are subject to sophisticated control, which takes place at the levels of both miRNA metabolism and function. In this chapter we focus on the recent advances in knowledge of the miRNA biogenesis pathways and regulatory mechanismsinvolved in miRNA gene transcription, processing, maturation and functionality. Potential impact of the alterations in miRNA biogenesis pathways on cancer pathogenesis is discussed.

Název v anglickém jazyce

MicroRNAs Biogenesis, Function and Decay

Popis výsledku anglicky

MicroRNAs (miRNAs) are important regulators of gene expression that control both physiological and pathological processes such as development and cancer. Research during the past decade has identified major factors participating in miRNA biogenesis and has established basic principles of miRNA function. Recent studies, however, have introduced a paradigm shift in our understanding of the miRNA biogenesis pathway, which was previously believed to be universal to all miRNAs. It has become apparent that miRNA regulators themselves are subject to sophisticated control, which takes place at the levels of both miRNA metabolism and function. In this chapter we focus on the recent advances in knowledge of the miRNA biogenesis pathways and regulatory mechanismsinvolved in miRNA gene transcription, processing, maturation and functionality. Potential impact of the alterations in miRNA biogenesis pathways on cancer pathogenesis is discussed.

Druh

C - Kapitola v odborné knize

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

MicroRNAs in Solid Cancer: From Biomarkers to Therapeutic Targets

ISBN

9781613245149

Počet stran výsledku

20

Strana od-do

1-20

Počet stran knihy

192

Název nakladatele

Nova Science Publishers, Inc.

Místo vydání

New York

Kód UT WoS kapitoly

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