The effect of felbamate on behavioural sensitisation to methamphetamine in mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F12%3A00061200" target="_blank" >RIV/00216224:14740/12:00061200 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16170/12:43870986

Výsledek na webu

<a href="http://vri.cz/docs/vetmed/57-7-364.pdf" target="_blank" >http://vri.cz/docs/vetmed/57-7-364.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The effect of felbamate on behavioural sensitisation to methamphetamine in mice

Popis výsledku v původním jazyce

It has been shown that methamphetamine (Met) similary to other psychostimulants induces a progressive augmentation of behavioural responses after repeated administration, so called behavioural sensitisation. Numerous studies refer to an important role for N-methyl-D-aspartate (NMDA) receptors in the development of behavioural sensitisation. Activating antiepileptic drugs of the newer second generation, such as felbamate (Eel), also invoke psychotropic effects. They may possess attention-enhancing and antidepressant activity, causing anxiety, insomnia, and agitation. Although not all pharmacological effects of felbamate are fully elucidated yet, many of its clinical effects may be related to the inhibition of NMDA currents. Thus, the present study was focused on investigating the influence of felbamate on sensitisation to the effects of methamphetamine on mouse locomotor behaviour in the Open field test.

Název v anglickém jazyce

The effect of felbamate on behavioural sensitisation to methamphetamine in mice

Popis výsledku anglicky

It has been shown that methamphetamine (Met) similary to other psychostimulants induces a progressive augmentation of behavioural responses after repeated administration, so called behavioural sensitisation. Numerous studies refer to an important role for N-methyl-D-aspartate (NMDA) receptors in the development of behavioural sensitisation. Activating antiepileptic drugs of the newer second generation, such as felbamate (Eel), also invoke psychotropic effects. They may possess attention-enhancing and antidepressant activity, causing anxiety, insomnia, and agitation. Although not all pharmacological effects of felbamate are fully elucidated yet, many of its clinical effects may be related to the inhibition of NMDA currents. Thus, the present study was focused on investigating the influence of felbamate on sensitisation to the effects of methamphetamine on mouse locomotor behaviour in the Open field test.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinarni Medicina

ISSN

0375-8427

e-ISSN

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Svazek periodika

57

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

364-370

Kód UT WoS článku

000307923600005

EID výsledku v databázi Scopus

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