EMT-related miRNAs as a potential markers for prediction and early detection of metastasis in renal cell carcinoma
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00065638" target="_blank" >RIV/00216224:14740/13:00065638 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
EMT-related miRNAs as a potential markers for prediction and early detection of metastasis in renal cell carcinoma
Popis výsledku v původním jazyce
Renal cell carcinoma (RCC) belongs among the most common adult kidney neoplasm. Because of the lack of early warning signals, a high percentage of patients with metastatic RCC occur. Nowadays, epithelial-mesenchymal transition (EMT) as a crucial event ofthe tumor progression resulting in metastasis is intensively studied. EMT is a biological process in which polarized epithelial cells undergo multiple biochemical changes altering their phenotype from epithelial to mesenchymal. This phenotype change observed during the tumor metastasis development is also accompanied on a molecular level by miRNAs deregulation. In our study, we try to identify EMT-related miRNAs that can be used in clinical practice as a predictors of metastatic risk and early relapseof the RCC. Five EMT-related miRNAs were studied on 3 different groups of RCC patients.
Název v anglickém jazyce
EMT-related miRNAs as a potential markers for prediction and early detection of metastasis in renal cell carcinoma
Popis výsledku anglicky
Renal cell carcinoma (RCC) belongs among the most common adult kidney neoplasm. Because of the lack of early warning signals, a high percentage of patients with metastatic RCC occur. Nowadays, epithelial-mesenchymal transition (EMT) as a crucial event ofthe tumor progression resulting in metastasis is intensively studied. EMT is a biological process in which polarized epithelial cells undergo multiple biochemical changes altering their phenotype from epithelial to mesenchymal. This phenotype change observed during the tumor metastasis development is also accompanied on a molecular level by miRNAs deregulation. In our study, we try to identify EMT-related miRNAs that can be used in clinical practice as a predictors of metastatic risk and early relapseof the RCC. Five EMT-related miRNAs were studied on 3 different groups of RCC patients.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/NT13547" target="_blank" >NT13547: Studium mikroRNA a genů asociovaných s procesem epiteliálně-mezenchymální tranzice jako potenciálních markerů pro predikci rizika a časný záchyt metastazování u pacientů s renálním karcinomem</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů