Similar circuits but different connectivity patterns between the cerebellum, Basal Ganglia, and supplementary motor area in early Parkinson's disease patients and controls during predictive motor timing

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00069968" target="_blank" >RIV/00216224:14740/13:00069968 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1111/jon.12030/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/jon.12030/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jon.12030" target="_blank" >10.1111/jon.12030</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Similar circuits but different connectivity patterns between the cerebellum, Basal Ganglia, and supplementary motor area in early Parkinson's disease patients and controls during predictive motor timing

Popis výsledku v původním jazyce

The cerebellum, basal ganglia (BG), and other cortical regions, such as supplementary motor area (SMA) have emerged as important structures dealing with various aspects of timing, yet the modulation of functional connectivity between them during motor timing tasks remains unexplored. METHODS: We used dynamic causal modeling to investigate the differences in effective connectivity (EC) between these regions and its modulation by behavioral outcome during a motor timing prediction task in a group of 16 patients with early Parkinson's disease (PD) and 17 healthy controls. Behavioral events (hits and errors) constituted the driving input connected to the cerebellum, and the modulation in connectivity was assessed relative to the hit condition (successful interception of target). RESULTS: The driving input elicited response in the target area, while modulatory input changed the specific connection strength.

Název v anglickém jazyce

Similar circuits but different connectivity patterns between the cerebellum, Basal Ganglia, and supplementary motor area in early Parkinson's disease patients and controls during predictive motor timing

Popis výsledku anglicky

The cerebellum, basal ganglia (BG), and other cortical regions, such as supplementary motor area (SMA) have emerged as important structures dealing with various aspects of timing, yet the modulation of functional connectivity between them during motor timing tasks remains unexplored. METHODS: We used dynamic causal modeling to investigate the differences in effective connectivity (EC) between these regions and its modulation by behavioral outcome during a motor timing prediction task in a group of 16 patients with early Parkinson's disease (PD) and 17 healthy controls. Behavioral events (hits and errors) constituted the driving input connected to the cerebellum, and the modulation in connectivity was assessed relative to the hit condition (successful interception of target). RESULTS: The driving input elicited response in the target area, while modulatory input changed the specific connection strength.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neuroimaging

ISSN

1051-2284

e-ISSN

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Svazek periodika

23

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

452-462

Kód UT WoS článku

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EID výsledku v databázi Scopus

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