Antigen selection in B-cell lymphomas-Tracing the evidence

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00072727" target="_blank" >RIV/00216224:14740/13:00072727 - isvavai.cz</a>

Výsledek na webu

<a href="http://ac.els-cdn.com/S1044579X1300076X/1-s2.0-S1044579X1300076X-main.pdf?_tid=53d1b2dc-bfba-11e3-91ac-00000aab0f6b&acdnat=1397029454_a5ad89568b55191984c5a6ad89549a75" target="_blank" >http://ac.els-cdn.com/S1044579X1300076X/1-s2.0-S1044579X1300076X-main.pdf?_tid=53d1b2dc-bfba-11e3-91ac-00000aab0f6b&acdnat=1397029454_a5ad89568b55191984c5a6ad89549a75</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.semcancer.2013.07.006" target="_blank" >10.1016/j.semcancer.2013.07.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antigen selection in B-cell lymphomas-Tracing the evidence

Popis výsledku v původním jazyce

While signaling through the B cell receptor (BcR) facilitates B cell development and maintenance, it also carries intertwined risks for the development of lymphomas since malignant B cells can exploit these pathways in order to trigger and fuel clonal expansion. This corruption of the normal B cell response to antigens, leading to sustained BcR signaling, has given great impulse to investigate in detail the role of antigen in lymphomas. Suffice it to conclude from such studies, largely immunogenetics based, that the evidence implicating antigens (exogenous or self) in lymphoma development is substantial and that lymphomagenesis is functionally driven and dynamic, rather than a simple stochastic process. As the paradigm of antigen-driven lymphoma evolves, further investigation will be paramount to the identification of the inciting agent(s) that may be responsible for immunoproliferative neoplasms and also for the development of therapeutic agents targeting effectors of the BcR signalin

Název v anglickém jazyce

Antigen selection in B-cell lymphomas-Tracing the evidence

Popis výsledku anglicky

While signaling through the B cell receptor (BcR) facilitates B cell development and maintenance, it also carries intertwined risks for the development of lymphomas since malignant B cells can exploit these pathways in order to trigger and fuel clonal expansion. This corruption of the normal B cell response to antigens, leading to sustained BcR signaling, has given great impulse to investigate in detail the role of antigen in lymphomas. Suffice it to conclude from such studies, largely immunogenetics based, that the evidence implicating antigens (exogenous or self) in lymphoma development is substantial and that lymphomagenesis is functionally driven and dynamic, rather than a simple stochastic process. As the paradigm of antigen-driven lymphoma evolves, further investigation will be paramount to the identification of the inciting agent(s) that may be responsible for immunoproliferative neoplasms and also for the development of therapeutic agents targeting effectors of the BcR signalin

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Seminars in Cancer Biology

ISSN

1044-579X

e-ISSN

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Svazek periodika

23

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

399-409

Kód UT WoS článku

000329011000002

EID výsledku v databázi Scopus

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