Stereotyped B Cell Receptors in B Cell Leukemias and Lymphomas

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00072871" target="_blank" >RIV/00216224:14740/13:00072871 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-1-62703-269-8_8" target="_blank" >http://dx.doi.org/10.1007/978-1-62703-269-8_8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-1-62703-269-8_8" target="_blank" >10.1007/978-1-62703-269-8_8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Stereotyped B Cell Receptors in B Cell Leukemias and Lymphomas

Popis výsledku v původním jazyce

Recent research has revealed the existence of subsets (clusters) of patients with different types of B-cell lymphomas and leukemias with restricted, ?stereotyped? immunoglobulin (IG) variable heavy complementarity-determining region 3 (VH CDR3) sequenceswithin their B cell receptors (BcR), suggesting selection by common epitopes or classes of structurally similar epitopes. BcR stereotypy was initially described in chronic lymphocytic leukemia (CLL), where it constitutes a remarkably frequent feature ofthe IG repertoire, and subsequently identified in other malignancies, including mantle cell lymphoma and splenic marginal-zone lymphoma. Of note, at least in CLL, emerging evidence indicates that the grouping of cases into distinct clusters with stereotyped BcR is functionally and prognostically relevant.

Název v anglickém jazyce

Stereotyped B Cell Receptors in B Cell Leukemias and Lymphomas

Popis výsledku anglicky

Recent research has revealed the existence of subsets (clusters) of patients with different types of B-cell lymphomas and leukemias with restricted, ?stereotyped? immunoglobulin (IG) variable heavy complementarity-determining region 3 (VH CDR3) sequenceswithin their B cell receptors (BcR), suggesting selection by common epitopes or classes of structurally similar epitopes. BcR stereotypy was initially described in chronic lymphocytic leukemia (CLL), where it constitutes a remarkably frequent feature ofthe IG repertoire, and subsequently identified in other malignancies, including mantle cell lymphoma and splenic marginal-zone lymphoma. Of note, at least in CLL, emerging evidence indicates that the grouping of cases into distinct clusters with stereotyped BcR is functionally and prognostically relevant.

Druh

C - Kapitola v odborné knize

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Lymphoma

ISBN

9781627032681

Počet stran výsledku

14

Strana od-do

135-148

Počet stran knihy

315

Název nakladatele

Humana Press

Místo vydání

London

Kód UT WoS kapitoly

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