Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F14%3A00074324" target="_blank" >RIV/00216224:14740/14:00074324 - isvavai.cz</a>

Výsledek na webu

<a href="https://iospress.metapress.com/content/e64v6362j4467140/resource-secured/?target=fulltext.pdf" target="_blank" >https://iospress.metapress.com/content/e64v6362j4467140/resource-secured/?target=fulltext.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3233/JAD-132684" target="_blank" >10.3233/JAD-132684</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease

Popis výsledku v původním jazyce

Background: The default mode network (DMN) decreases its activity when switching from a resting state to a cognitive task condition, while activity of the network engaged in the given task increases. Visual processing is typically disturbed in Parkinson's disease dementia (PDD). Objective: Using functional MRI, we studied the DMN effective connectivity patterns in PDD as compared with cognitively normal patients with Parkinson's disease (PD) and healthy controls (HC) when switching from baseline to a visual cognitive task condition. Methods: In all, 14 PDD, 18 PD, and 18 age-matched healthy controls participated in this functional MRI study. We used a psychophysiological interaction analysis with the precuneus (PCu) as a seed. The threshold was set atp(FWE) &lt;0.05. Results: The healthy controls showed greater PCu connectivity with the bilateral middle temporal/middle occipital gyri at baseline than during the task condition. The correlation direction changed from positive to negativ

Název v anglickém jazyce

Default Mode Network Connectivity Patterns associated with Visual Processing at Different Stages of Parkinson's Disease

Popis výsledku anglicky

Background: The default mode network (DMN) decreases its activity when switching from a resting state to a cognitive task condition, while activity of the network engaged in the given task increases. Visual processing is typically disturbed in Parkinson's disease dementia (PDD). Objective: Using functional MRI, we studied the DMN effective connectivity patterns in PDD as compared with cognitively normal patients with Parkinson's disease (PD) and healthy controls (HC) when switching from baseline to a visual cognitive task condition. Methods: In all, 14 PDD, 18 PD, and 18 age-matched healthy controls participated in this functional MRI study. We used a psychophysiological interaction analysis with the precuneus (PCu) as a seed. The threshold was set atp(FWE) &lt;0.05. Results: The healthy controls showed greater PCu connectivity with the bilateral middle temporal/middle occipital gyri at baseline than during the task condition. The correlation direction changed from positive to negativ

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF ALZHEIMERS DISEASE

ISSN

1387-2877

e-ISSN

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Svazek periodika

42

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

"S217"-"S228"

Kód UT WoS článku

000341595800023

EID výsledku v databázi Scopus

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