Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F14%3A00074326" target="_blank" >RIV/00216224:14740/14:00074326 - isvavai.cz</a>

Výsledek na webu

<a href="https://iospress.metapress.com/content/y7477621420j4145/resource-secured/?target=fulltext.pdf" target="_blank" >https://iospress.metapress.com/content/y7477621420j4145/resource-secured/?target=fulltext.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3233/JAD-131208" target="_blank" >10.3233/JAD-131208</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing

Popis výsledku v původním jazyce

Changes in connectivity of the posterior node of the default mode network (DMN) were studied when switching from baseline to a cognitive task using functional magnetic resonance imaging. In all, 15 patients with mild to moderate Alzheimer's disease (AD)and 18 age-, gender-, and education-matched healthy controls (HC) participated in the study. Psychophysiological interactions analysis was used to assess the specific alterations in the DMN connectivity (deactivation-based) due to psychological effects from the complex visual scene encoding task. In HC, we observed task-induced connectivity decreases between the posterior cingulate and middle temporal and occipital visual cortices. These findings imply successful involvement of the ventral visual pathway during the visual processing in our HC cohort. In AD, involvement of the areas engaged in the ventral visual pathway was observed only in a small volume of the right middle temporal gyrus.

Název v anglickém jazyce

Disturbed Default Mode Network Connectivity Patterns in Alzheimer's Disease Associated with Visual Processing

Popis výsledku anglicky

Changes in connectivity of the posterior node of the default mode network (DMN) were studied when switching from baseline to a cognitive task using functional magnetic resonance imaging. In all, 15 patients with mild to moderate Alzheimer's disease (AD)and 18 age-, gender-, and education-matched healthy controls (HC) participated in the study. Psychophysiological interactions analysis was used to assess the specific alterations in the DMN connectivity (deactivation-based) due to psychological effects from the complex visual scene encoding task. In HC, we observed task-induced connectivity decreases between the posterior cingulate and middle temporal and occipital visual cortices. These findings imply successful involvement of the ventral visual pathway during the visual processing in our HC cohort. In AD, involvement of the areas engaged in the ventral visual pathway was observed only in a small volume of the right middle temporal gyrus.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF ALZHEIMERS DISEASE

ISSN

1387-2877

e-ISSN

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Svazek periodika

41

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

1229-1238

Kód UT WoS článku

000340488400019

EID výsledku v databázi Scopus

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