Quadruplex-forming DNA sequences spread by retrotransposons may serve as genome regulators

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F14%3A00075019" target="_blank" >RIV/00216224:14740/14:00075019 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.landesbioscience.com/journals/mge/article/28084/" target="_blank" >https://www.landesbioscience.com/journals/mge/article/28084/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4161/mge.28084" target="_blank" >10.4161/mge.28084</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Quadruplex-forming DNA sequences spread by retrotransposons may serve as genome regulators

Popis výsledku v původním jazyce

Transposable elements (TEs) are ubiquitous genome inhabitants in eukaryotes. Increasing evidence shows that TEs are involved in regulatory networks of eukaryotic cells and contribute to genome evolution. Recently, we reported that many plant long-terminal repeat (LTR) retrotransposons contain DNA quadruplex-forming sequences at precise positions inside their LTRs and that quadruplexes are better preserved in evolutionary younger elements. As quadruplexes can modulate molecular processes, quadruplexes found at specific distances upstream and downstream from the endogenous TE promoter can affect transcription of the element. Moreover, quadruplexes found in solo LTRs, as well as in 3 ends of 5-truncated copies of LINE-1 elements, can affect expression ofneighboring genes. Here, we propose that this way retrotransposons can serve as vehicles for spread of DNA quadruplexes.

Název v anglickém jazyce

Quadruplex-forming DNA sequences spread by retrotransposons may serve as genome regulators

Popis výsledku anglicky

Transposable elements (TEs) are ubiquitous genome inhabitants in eukaryotes. Increasing evidence shows that TEs are involved in regulatory networks of eukaryotic cells and contribute to genome evolution. Recently, we reported that many plant long-terminal repeat (LTR) retrotransposons contain DNA quadruplex-forming sequences at precise positions inside their LTRs and that quadruplexes are better preserved in evolutionary younger elements. As quadruplexes can modulate molecular processes, quadruplexes found at specific distances upstream and downstream from the endogenous TE promoter can affect transcription of the element. Moreover, quadruplexes found in solo LTRs, as well as in 3 ends of 5-truncated copies of LINE-1 elements, can affect expression ofneighboring genes. Here, we propose that this way retrotransposons can serve as vehicles for spread of DNA quadruplexes.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mobile Genetic Elements

ISSN

2159-256X

e-ISSN

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Svazek periodika

4

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

"e28084"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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