Non-invasive brain stimulation of the right inferior frontal gyrus may improve attention in early Alzheimer?s disease: A pilot study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F14%3A00076257" target="_blank" >RIV/00216224:14740/14:00076257 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0022510X14005681#" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0022510X14005681#</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jns.2014.08.036" target="_blank" >10.1016/j.jns.2014.08.036</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Non-invasive brain stimulation of the right inferior frontal gyrus may improve attention in early Alzheimer?s disease: A pilot study

Popis výsledku v původním jazyce

Introduction Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive tool for modulating cortical activity. Objectives In this pilot study, we evaluated the effects of high frequency rTMS applied over the right inferior frontal gyrus (IFG) on cognitive functions in patients with amnestic mild cognitive impairment (MCI) or incipient dementia due to Alzheimer?s disease (AD). Methods Ten patients (6 men; 4 women, mean age 72 ? 8 years; MMSE 23 ? 3.56) were enrolled in a randomized, placebo-controlled study with a crossover design. All participants received 2 sessions of 10 Hz rTMS over the non-dominant right hemisphere in random order: IFG (active stimulation site) and vertex (control stimulation site). Intensities were adjusted to 90% of resting motor threshold. A total of 2250 pulses were applied in a session. The Trail Making Test (TMT), the Stroop test, and the complex visual scene encoding task (CVSET) were administered before and immediately after each session.

Název v anglickém jazyce

Non-invasive brain stimulation of the right inferior frontal gyrus may improve attention in early Alzheimer?s disease: A pilot study

Popis výsledku anglicky

Introduction Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive tool for modulating cortical activity. Objectives In this pilot study, we evaluated the effects of high frequency rTMS applied over the right inferior frontal gyrus (IFG) on cognitive functions in patients with amnestic mild cognitive impairment (MCI) or incipient dementia due to Alzheimer?s disease (AD). Methods Ten patients (6 men; 4 women, mean age 72 ? 8 years; MMSE 23 ? 3.56) were enrolled in a randomized, placebo-controlled study with a crossover design. All participants received 2 sessions of 10 Hz rTMS over the non-dominant right hemisphere in random order: IFG (active stimulation site) and vertex (control stimulation site). Intensities were adjusted to 90% of resting motor threshold. A total of 2250 pulses were applied in a session. The Trail Making Test (TMT), the Stroop test, and the complex visual scene encoding task (CVSET) were administered before and immediately after each session.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the neurological sciences

ISSN

0022-510X

e-ISSN

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Svazek periodika

346

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

318-322

Kód UT WoS článku

000345947400055

EID výsledku v databázi Scopus

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