Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer?s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00083300" target="_blank" >RIV/00216224:14740/15:00083300 - isvavai.cz</a>

Výsledek na webu

<a href="http://content.iospress.com/articles/journal-of-alzheimers-disease/jad150067" target="_blank" >http://content.iospress.com/articles/journal-of-alzheimers-disease/jad150067</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3233/JAD-150067" target="_blank" >10.3233/JAD-150067</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer?s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation

Popis výsledku v původním jazyce

Background: Repetitive transcranial magnetic stimulation (rTMS) is a promising tool to study and modulate brain plasticity. Objective: Our aim was to investigate the effects of rTMS on cognitive functions in patients with mild cognitive impairment and Alzheimer?s disease (MCI/AD) and assess the effect of gray matter (GM) atrophy on stimulation outcomes. Methods: Twenty MCI/AD patients participated in the proof-of-concept controlled study. Each patient received three sessions of 10 Hz rTMS of the right inferior frontal gyrus (IFG), the right superior temporal gyrus (STG), and the vertex (VTX, a control stimulation site) in a randomized order. Cognitive functions were tested prior to and immediately after each session. The GM volumetric data of patientswere: 1)compared to healthy controls (HC) using source-based morphometry; 2) correlated with rTMS-induced cognitive improvement.

Název v anglickém jazyce

Distinct Pattern of Gray Matter Atrophy in Mild Alzheimer?s Disease Impacts on Cognitive Outcomes of Noninvasive Brain Stimulation

Popis výsledku anglicky

Background: Repetitive transcranial magnetic stimulation (rTMS) is a promising tool to study and modulate brain plasticity. Objective: Our aim was to investigate the effects of rTMS on cognitive functions in patients with mild cognitive impairment and Alzheimer?s disease (MCI/AD) and assess the effect of gray matter (GM) atrophy on stimulation outcomes. Methods: Twenty MCI/AD patients participated in the proof-of-concept controlled study. Each patient received three sessions of 10 Hz rTMS of the right inferior frontal gyrus (IFG), the right superior temporal gyrus (STG), and the vertex (VTX, a control stimulation site) in a randomized order. Cognitive functions were tested prior to and immediately after each session. The GM volumetric data of patientswere: 1)compared to healthy controls (HC) using source-based morphometry; 2) correlated with rTMS-induced cognitive improvement.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF ALZHEIMERS DISEASE

ISSN

1387-2877

e-ISSN

—

Svazek periodika

48

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

251-260

Kód UT WoS článku

000360931700023

EID výsledku v databázi Scopus

—