Computational fluid dynamics-based design of a microfabricated cell capture device.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00082639" target="_blank" >RIV/00216224:14740/15:00082639 - isvavai.cz</a>

Výsledek na webu

<a href="http://chromsci.oxfordjournals.org/content/53/3/411.long" target="_blank" >http://chromsci.oxfordjournals.org/content/53/3/411.long</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/chromsci/bmu110" target="_blank" >10.1093/chromsci/bmu110</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Computational fluid dynamics-based design of a microfabricated cell capture device.

Popis výsledku v původním jazyce

A microfluidic cell capture device was designed, fabricated, evaluated by numerical simulations and validated experimentally. The cell capture device was designed with a minimal footprint compartment comprising internal micropillars with the goal to obtain a compact, integrated bioanalytical system. The design of the device was accomplished by computational fluid dynamics (CFD) simulations. Various microdevice designs were rapidly prototyped in poly-dimethylsiloxane using conventional soft lithograpy technique applying micropatterned SU-8 epoxy based negative photoresist as moulding replica. The numerically modeled flow characteristics of the cell capture device were experimentally validated by tracing and microscopic recording the flow trajectories using yeast cells. Finally, we give some perspectives on how CFD modeling can be used in the early stage of microfluidics-based cell capture device development.

Název v anglickém jazyce

Computational fluid dynamics-based design of a microfabricated cell capture device.

Popis výsledku anglicky

A microfluidic cell capture device was designed, fabricated, evaluated by numerical simulations and validated experimentally. The cell capture device was designed with a minimal footprint compartment comprising internal micropillars with the goal to obtain a compact, integrated bioanalytical system. The design of the device was accomplished by computational fluid dynamics (CFD) simulations. Various microdevice designs were rapidly prototyped in poly-dimethylsiloxane using conventional soft lithograpy technique applying micropatterned SU-8 epoxy based negative photoresist as moulding replica. The numerically modeled flow characteristics of the cell capture device were experimentally validated by tracing and microscopic recording the flow trajectories using yeast cells. Finally, we give some perspectives on how CFD modeling can be used in the early stage of microfluidics-based cell capture device development.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

<a href="/cs/project/EE2.3.30.0037" target="_blank" >EE2.3.30.0037: Zaměstnáním nejlepších mladých vědců k rozvoji mezinárodní spolupráce</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Chromatographic Science

ISSN

0021-9665

e-ISSN

—

Svazek periodika

53

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

411-416

Kód UT WoS článku

000354695600004

EID výsledku v databázi Scopus

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