Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00082816" target="_blank" >RIV/00216224:14740/15:00082816 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.nature.com/jcbfm/journal/v35/n4/full/jcbfm2014233a.html" target="_blank" >http://www.nature.com/jcbfm/journal/v35/n4/full/jcbfm2014233a.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/jcbfm.2014.233" target="_blank" >10.1038/jcbfm.2014.233</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla

Popis výsledku v původním jazyce

Several laboratories have consistently reported small concentration changes in lactate, glutamate, aspartate, and glucose in the human cortex during prolonged stimuli. However, whether such changes correlate with blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-fMRI) signals have not been determined. The present study aimed at characterizing the relationship between metabolite concentrations and BOLD-fMRI signals during a block-designed paradigm of visual stimulation. Functional magnetic resonance spectroscopy (fMRS) and fMRI data were acquired from 12 volunteers. A short echo-time semiLASER localization sequence optimized for 7 Tesla was used to achieve full signal-intensity MRS data. The group analysis confirmed that during stimulation lactate and glutamate increased by 0.26 +/- 0.06 mu mol/g (similar to 30%) and 0.28 +/- 0.03 mu mol/g (similar to 3%), respectively, while aspartate and glucose decreased by 0.20 +/- 0.04 mu mol/g (similar to 5%) and 0.19 +

Název v anglickém jazyce

Neurochemical and BOLD responses during neuronal activation measured in the human visual cortex at 7 Tesla

Popis výsledku anglicky

Several laboratories have consistently reported small concentration changes in lactate, glutamate, aspartate, and glucose in the human cortex during prolonged stimuli. However, whether such changes correlate with blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-fMRI) signals have not been determined. The present study aimed at characterizing the relationship between metabolite concentrations and BOLD-fMRI signals during a block-designed paradigm of visual stimulation. Functional magnetic resonance spectroscopy (fMRS) and fMRI data were acquired from 12 volunteers. A short echo-time semiLASER localization sequence optimized for 7 Tesla was used to achieve full signal-intensity MRS data. The group analysis confirmed that during stimulation lactate and glutamate increased by 0.26 +/- 0.06 mu mol/g (similar to 30%) and 0.28 +/- 0.03 mu mol/g (similar to 3%), respectively, while aspartate and glucose decreased by 0.20 +/- 0.04 mu mol/g (similar to 5%) and 0.19 +

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

ISSN

0271-678X

e-ISSN

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Svazek periodika

35

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

601-610

Kód UT WoS článku

000352027900010

EID výsledku v databázi Scopus

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