2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00084725" target="_blank" >RIV/00216224:14740/15:00084725 - isvavai.cz</a>

Výsledek na webu

<a href="http://download.springer.com/static/pdf/322/art%253A10.1007%252Fs00213-015-3917-y.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00213-015-3917-y&token2=exp=1447855112~acl=%2Fstatic%2Fpdf%2F322%2Fart%25253A10.1007%25252Fs00213-015-39" target="_blank" >http://download.springer.com/static/pdf/322/art%253A10.1007%252Fs00213-015-3917-y.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00213-015-3917-y&token2=exp=1447855112~acl=%2Fstatic%2Fpdf%2F322%2Fart%25253A10.1007%25252Fs00213-015-39</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00213-015-3917-y" target="_blank" >10.1007/s00213-015-3917-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons

Popis výsledku v původním jazyce

The contribution of two major endocannabinoids, 2-arachidonoylglycerol (2-AG) and anandamide (AEA), in the regulation of fear expression is still unknown. We analyzed the role of different players of the endocannabinoid system on the expression of a strong auditory-cued fear memory in male mice by pharmacological means. The cannabinoid receptor type 1 (CB1) antagonist SR141716 (3 mg/kg) caused an increase in conditioned freezing upon repeated tone presentation on three consecutive days. The cannabinoidreceptor type 2 (CB2) antagonist AM630 (3 mg/kg), in contrast, had opposite effects during the first tone presentation, with no effects of the transient receptor potential vanilloid receptor type 1 (TRPV1) antagonist SB366791 (1 and 3 mg/kg). Administration of the CB2 agonist JWH133 (3 mg/kg) failed to affect the acute freezing response, whereas the CB1 agonist CP55,940 (50 mu g/kg) augmented it.

Název v anglickém jazyce

2-AG promotes the expression of conditioned fear via cannabinoid receptor type 1 on GABAergic neurons

Popis výsledku anglicky

The contribution of two major endocannabinoids, 2-arachidonoylglycerol (2-AG) and anandamide (AEA), in the regulation of fear expression is still unknown. We analyzed the role of different players of the endocannabinoid system on the expression of a strong auditory-cued fear memory in male mice by pharmacological means. The cannabinoid receptor type 1 (CB1) antagonist SR141716 (3 mg/kg) caused an increase in conditioned freezing upon repeated tone presentation on three consecutive days. The cannabinoidreceptor type 2 (CB2) antagonist AM630 (3 mg/kg), in contrast, had opposite effects during the first tone presentation, with no effects of the transient receptor potential vanilloid receptor type 1 (TRPV1) antagonist SB366791 (1 and 3 mg/kg). Administration of the CB2 agonist JWH133 (3 mg/kg) failed to affect the acute freezing response, whereas the CB1 agonist CP55,940 (50 mu g/kg) augmented it.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychopharmacology

ISSN

0033-3158

e-ISSN

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Svazek periodika

232

Číslo periodika v rámci svazku

15

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

2811-2825

Kód UT WoS článku

000358059700015

EID výsledku v databázi Scopus

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