Dynamics of Individual T Cell Repertoires: From Cord Blood to Centenarians

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00090973" target="_blank" >RIV/00216224:14740/16:00090973 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.jimmunol.org/content/196/12/5005" target="_blank" >http://www.jimmunol.org/content/196/12/5005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4049/jimmunol.1600005" target="_blank" >10.4049/jimmunol.1600005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dynamics of Individual T Cell Repertoires: From Cord Blood to Centenarians

Popis výsledku v původním jazyce

The diversity, architecture, and dynamics of the TCR repertoire largely determine our ability to effectively withstand infections and malignancies with minimal mistargeting of immune responses. In this study, we have employed deep TCRb repertoire sequencing with normalization based on unique molecular identifiers to explore the long-term dynamics of T cell immunity. We demonstrate remarkable stability of repertoire, where approximately half of all T cells in peripheral blood are represented by clones that persist and generally preserve their frequencies for 3 y. We further characterize the extremes of lifelong TCR repertoire evolution, analyzing samples ranging from umbilical cord blood to centenarian peripheral blood. We show that the fetal TCR repertoire, albeit structurally maintained within regulated borders due to the lower numbers of randomly added nucleotides, is not limited with respect to observed functional diversity.

Název v anglickém jazyce

Dynamics of Individual T Cell Repertoires: From Cord Blood to Centenarians

Popis výsledku anglicky

The diversity, architecture, and dynamics of the TCR repertoire largely determine our ability to effectively withstand infections and malignancies with minimal mistargeting of immune responses. In this study, we have employed deep TCRb repertoire sequencing with normalization based on unique molecular identifiers to explore the long-term dynamics of T cell immunity. We demonstrate remarkable stability of repertoire, where approximately half of all T cells in peripheral blood are represented by clones that persist and generally preserve their frequencies for 3 y. We further characterize the extremes of lifelong TCR repertoire evolution, analyzing samples ranging from umbilical cord blood to centenarian peripheral blood. We show that the fetal TCR repertoire, albeit structurally maintained within regulated borders due to the lower numbers of randomly added nucleotides, is not limited with respect to observed functional diversity.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FN - Epidemiologie, infekční nemoci a klinická imunologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of immunology

ISSN

0022-1767

e-ISSN

—

Svazek periodika

196

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

5005-5013

Kód UT WoS článku

000377937500018

EID výsledku v databázi Scopus

—