Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00092576" target="_blank" >RIV/00216224:14740/16:00092576 - isvavai.cz</a>
Výsledek na webu
<a href="http://onlinelibrary.wiley.com/doi/10.1111/jnc.13390/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/jnc.13390/epdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/jnc.13390" target="_blank" >10.1111/jnc.13390</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders
Popis výsledku v původním jazyce
Cerebrospinal fluid (CSF) has been extensively studied to explore biochemical alterations in subjects with neurodegenerative disorders. In Alzheimer's disease, levels of increased CSF tau protein and decreased levels of -amyloid 1-42 (A42) have been shown to correlate with brain plaque formation and tangle pathology. Intracellular Lewy inclusions containing aggregated -synuclein (-syn) represent a pathological hallmark of Parkinson's disease (PD). In most - but not all - studies published to date total CSF -syn concentrations have been found to be decreased in disorders related to -syn pathology, that is, PD, dementia with Lewy bodies and multiple system atrophy. However, these reports show extensive signal overlap among tested individuals, thereby diminishing its potential for routine use in clinical practice. To investigate potential biological (i.e.
Název v anglickém jazyce
Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders
Popis výsledku anglicky
Cerebrospinal fluid (CSF) has been extensively studied to explore biochemical alterations in subjects with neurodegenerative disorders. In Alzheimer's disease, levels of increased CSF tau protein and decreased levels of -amyloid 1-42 (A42) have been shown to correlate with brain plaque formation and tangle pathology. Intracellular Lewy inclusions containing aggregated -synuclein (-syn) represent a pathological hallmark of Parkinson's disease (PD). In most - but not all - studies published to date total CSF -syn concentrations have been found to be decreased in disorders related to -syn pathology, that is, PD, dementia with Lewy bodies and multiple system atrophy. However, these reports show extensive signal overlap among tested individuals, thereby diminishing its potential for routine use in clinical practice. To investigate potential biological (i.e.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FH - Neurologie, neurochirurgie, neurovědy
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: CEITEC - central european institute of technology</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Neurochemistry
ISSN
0022-3042
e-ISSN
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Svazek periodika
139
Číslo periodika v rámci svazku
October
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
28
Strana od-do
290-317
Kód UT WoS článku
000385770500019
EID výsledku v databázi Scopus
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