The role of 3 ' end uridylation in RNA metabolism and cellular physiology

Kód výsledku v IS VaVaI

RIV/00216224:14740/18:00101443 - isvavai.cz

Výsledek na webu

http://dx.doi.org/10.1098/rstb.2018.0171

DOI - Digital Object Identifier

10.1098/rstb.2018.0171

Jazyk výsledku

angličtina

Název v původním jazyce

The role of 3 ' end uridylation in RNA metabolism and cellular physiology

Popis výsledku v původním jazyce

Most eukaryotic RNAs are posttranscriptionally modified. The majority of modifications promote RNA maturation, others may regulate function and stability. The 3' terminal non-templated oligouridylation is a widespread modification affecting many cellular RNAs at some stage of their life cycle. It has diverse roles in RNA metabolism. The most prevalent is the regulation of stability and quality control. On the cellular and organismal level, it plays a critical role in a number of pathways, such as cell cycle regulation, cell death, development or viral infection. Defects in uridylation have been linked to several diseases. This review summarizes the current knowledge about the role of the 3' terminal oligo(U)-tailing in biology of various RNAs in eukaryotes and describes key factors involved in these pathways. This article is part of the theme issue '5' and 3' modifications controlling RNA degradation'.

Název v anglickém jazyce

The role of 3 ' end uridylation in RNA metabolism and cellular physiology

Popis výsledku anglicky

Most eukaryotic RNAs are posttranscriptionally modified. The majority of modifications promote RNA maturation, others may regulate function and stability. The 3' terminal non-templated oligouridylation is a widespread modification affecting many cellular RNAs at some stage of their life cycle. It has diverse roles in RNA metabolism. The most prevalent is the regulation of stability and quality control. On the cellular and organismal level, it plays a critical role in a number of pathways, such as cell cycle regulation, cell death, development or viral infection. Defects in uridylation have been linked to several diseases. This review summarizes the current knowledge about the role of the 3' terminal oligo(U)-tailing in biology of various RNAs in eukaryotes and describes key factors involved in these pathways. This article is part of the theme issue '5' and 3' modifications controlling RNA degradation'.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

ISSN

0962-8436

e-ISSN

—

Svazek periodika

373

Číslo periodika v rámci svazku

1762

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

20180171

Kód UT WoS článku

000449345600011

EID výsledku v databázi Scopus

2-s2.0-85056256514