RNA methylation in nuclear pre-mRNA processing

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00101444" target="_blank" >RIV/00216224:14740/18:00101444 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/wrna.1489" target="_blank" >http://dx.doi.org/10.1002/wrna.1489</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/wrna.1489" target="_blank" >10.1002/wrna.1489</a>

Jazyk výsledku

angličtina

Název v původním jazyce

RNA methylation in nuclear pre-mRNA processing

Popis výsledku v původním jazyce

Eukaryotic RNA can carry more than 100 different types of chemical modifications. Early studies have been focused on modifications of highly abundant RNA, such as ribosomal RNA and transfer RNA, but recent technical advances have made it possible to also study messenger RNA (mRNA). Subsequently, mRNA modifications, namely methylation, have emerged as key players in eukaryotic gene expression regulation. The most abundant and widely studied internal mRNA modification is N-6-methyladenosine (m(6)A), but the list of mRNA chemical modifications continues to grow as fast as interest in this field. Over the past decade, transcriptome-wide studies combined with advanced biochemistry and the discovery of methylation writers, readers, and erasers revealed roles for mRNA methylation in the regulation of nearly every aspect of the mRNA life cycle and in diverse cellular, developmental, and disease processes. Although large parts of mRNA function are linked to its cytoplasmic stability and regulation of its translation, a number of studies have begun to provide evidence for methylation-regulated nuclear processes. In this review, we summarize the recent advances in RNA methylation research and highlight how these new findings have contributed to our understanding of methylation-dependent RNA processing in the nucleus. This article is categorized under: RNA Processing &gt; RNA Editing and Modification RNA Processing &gt; Splicing Regulation/Alternative Splicing RNA Interactions with Proteins and Other Molecules &gt; Protein-RNA Interactions: Functional Implications

Název v anglickém jazyce

RNA methylation in nuclear pre-mRNA processing

Popis výsledku anglicky

Eukaryotic RNA can carry more than 100 different types of chemical modifications. Early studies have been focused on modifications of highly abundant RNA, such as ribosomal RNA and transfer RNA, but recent technical advances have made it possible to also study messenger RNA (mRNA). Subsequently, mRNA modifications, namely methylation, have emerged as key players in eukaryotic gene expression regulation. The most abundant and widely studied internal mRNA modification is N-6-methyladenosine (m(6)A), but the list of mRNA chemical modifications continues to grow as fast as interest in this field. Over the past decade, transcriptome-wide studies combined with advanced biochemistry and the discovery of methylation writers, readers, and erasers revealed roles for mRNA methylation in the regulation of nearly every aspect of the mRNA life cycle and in diverse cellular, developmental, and disease processes. Although large parts of mRNA function are linked to its cytoplasmic stability and regulation of its translation, a number of studies have begun to provide evidence for methylation-regulated nuclear processes. In this review, we summarize the recent advances in RNA methylation research and highlight how these new findings have contributed to our understanding of methylation-dependent RNA processing in the nucleus. This article is categorized under: RNA Processing &gt; RNA Editing and Modification RNA Processing &gt; Splicing Regulation/Alternative Splicing RNA Interactions with Proteins and Other Molecules &gt; Protein-RNA Interactions: Functional Implications

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Wiley Interdisciplinary Reviews: RNA

ISSN

1757-7004

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

17

Strana od-do

1489

Kód UT WoS článku

000447167100001

EID výsledku v databázi Scopus

2-s2.0-85052365969