Interplays of different types of epitranscriptomic mRNA modifications
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F21%3A00124288" target="_blank" >RIV/00216224:14740/21:00124288 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.tandfonline.com/doi/full/10.1080/15476286.2021.1969113" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/15476286.2021.1969113</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15476286.2021.1969113" target="_blank" >10.1080/15476286.2021.1969113</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Interplays of different types of epitranscriptomic mRNA modifications
Popis výsledku v původním jazyce
Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m(6)A and ADAR RNA editing. Recent studies have also identified additional mRNA marks such as m(6)Am, m(5)C, m(1)A and psi and studied their roles. Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. Several works have addressed the functional relationships between some of the modifications. In this review we provide an overview on the current status of research on the different types of mRNA modifications and about the crosstalk between different marks and its functional consequences.
Název v anglickém jazyce
Interplays of different types of epitranscriptomic mRNA modifications
Popis výsledku anglicky
Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m(6)A and ADAR RNA editing. Recent studies have also identified additional mRNA marks such as m(6)Am, m(5)C, m(1)A and psi and studied their roles. Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. Several works have addressed the functional relationships between some of the modifications. In this review we provide an overview on the current status of research on the different types of mRNA modifications and about the crosstalk between different marks and its functional consequences.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10608 - Biochemistry and molecular biology
Návaznosti výsledku
Projekt
<a href="/cs/project/LTC18052" target="_blank" >LTC18052: Integrativní studium molekulárních mechanismů epitranskriptomu savčích buněk</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
RNA Biology
ISSN
1547-6286
e-ISSN
—
Svazek periodika
18
Číslo periodika v rámci svazku
S1
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
12
Strana od-do
19-30
Kód UT WoS článku
000687601700001
EID výsledku v databázi Scopus
2-s2.0-85113759012