The role of RNA adenosine demethylases in the control of gene expression

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F19%3A00109891" target="_blank" >RIV/00216224:14740/19:00109891 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1874939918300439?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1874939918300439?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbagrm.2018.12.001" target="_blank" >10.1016/j.bbagrm.2018.12.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of RNA adenosine demethylases in the control of gene expression

Popis výsledku v původním jazyce

RNA modifications are being recognized as an essential factor in gene expression regulation. They play essential roles in germ line development, differentiation and disease. In eukaryotic mRNAs, N-6-adenosine methylation (m(6)A) is the most prevalent internal chemical modification identified to date. The m(6)A pathway involves factors called writers, readers and erasers. m(6)A thus offers an interesting concept of dynamic reversible modification with implications in fine-tuning the cellular metabolism. In mammals, FTO and ALKBH5 have been initially identified as m(6)A erasers. Recently, FTO m(6)A specificity has been debated as new reports identify FTO targeting N-6,2'-O-dimethyladenosine (m(6)A(m)). The two adenosine demethylases have diverse roles in the metabolism of mRNAs and their activity is involved in key processes, such as embryogenesis, disease or infection. In this article, we review the current knowledge of their function and mechanisms and discuss the existing contradictions in the field. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert.

Název v anglickém jazyce

The role of RNA adenosine demethylases in the control of gene expression

Popis výsledku anglicky

RNA modifications are being recognized as an essential factor in gene expression regulation. They play essential roles in germ line development, differentiation and disease. In eukaryotic mRNAs, N-6-adenosine methylation (m(6)A) is the most prevalent internal chemical modification identified to date. The m(6)A pathway involves factors called writers, readers and erasers. m(6)A thus offers an interesting concept of dynamic reversible modification with implications in fine-tuning the cellular metabolism. In mammals, FTO and ALKBH5 have been initially identified as m(6)A erasers. Recently, FTO m(6)A specificity has been debated as new reports identify FTO targeting N-6,2'-O-dimethyladenosine (m(6)A(m)). The two adenosine demethylases have diverse roles in the metabolism of mRNAs and their activity is involved in key processes, such as embryogenesis, disease or infection. In this article, we review the current knowledge of their function and mechanisms and discuss the existing contradictions in the field. This article is part of a Special Issue entitled: mRNA modifications in gene expression control edited by Dr. Soller Matthias and Dr. Fray Rupert.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biochimica et biophysica acta - Gene regulatory mechanisms

ISSN

1874-9399

e-ISSN

—

Svazek periodika

1862

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

13

Strana od-do

343-355

Kód UT WoS článku

000462104500013

EID výsledku v databázi Scopus

2-s2.0-85058499927