Advances in the cellular structural biology of nucleic acids

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00101748" target="_blank" >RIV/00216224:14740/18:00101748 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081707:_____/18:00502737

Výsledek na webu

<a href="http://dx.doi.org/10.1002/1873-3468.13054" target="_blank" >http://dx.doi.org/10.1002/1873-3468.13054</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/1873-3468.13054" target="_blank" >10.1002/1873-3468.13054</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Advances in the cellular structural biology of nucleic acids

Popis výsledku v původním jazyce

Conventional biophysical and chemical biology approaches for delineating relationships between the structure and biological function of nucleic acids (NAs) abstract NAs from their native biological context. However, cumulative experimental observations have revealed that the structure, dynamics and interactions of NAs might be strongly influenced by a broad spectrum of specific and nonspecific physical-chemical environmental factors. This consideration has recently sparked interest in the development of novel tools for structural characterization of NAs in the native cellular context. Here, we review the individual methods currently being employed for structural characterization of NA structure in a native cellular environment with a focus on recent advances and developments in the emerging fields of in-cell NMR and electron paramagnetic resonance spectroscopy and in-cell single-molecule FRET of NAs.

Název v anglickém jazyce

Advances in the cellular structural biology of nucleic acids

Popis výsledku anglicky

Conventional biophysical and chemical biology approaches for delineating relationships between the structure and biological function of nucleic acids (NAs) abstract NAs from their native biological context. However, cumulative experimental observations have revealed that the structure, dynamics and interactions of NAs might be strongly influenced by a broad spectrum of specific and nonspecific physical-chemical environmental factors. This consideration has recently sparked interest in the development of novel tools for structural characterization of NAs in the native cellular context. Here, we review the individual methods currently being employed for structural characterization of NA structure in a native cellular environment with a focus on recent advances and developments in the emerging fields of in-cell NMR and electron paramagnetic resonance spectroscopy and in-cell single-molecule FRET of NAs.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

FEBS LETTERS

ISSN

1873-3468

e-ISSN

—

Svazek periodika

592

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

1997-2011

Kód UT WoS článku

000436109600009

EID výsledku v databázi Scopus

2-s2.0-85046267649