Staufen1 reads out structure and sequence features in ARF1 SBS for specific target recognition
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00101765" target="_blank" >RIV/00216224:14740/18:00101765 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Staufen1 reads out structure and sequence features in ARF1 SBS for specific target recognition
Popis výsledku v původním jazyce
Most posttranscriptional regulation of gene expression is based on RNA elements in mRNAs recognized by RNAbinding proteins (RBPs). Besides primary sequence elements, a second layer of information is embedded in 3’UTRs of mRNAs in the form of RNA structure. Doublestranded RBPs can bind structures in 3’UTRs and then exert their function based on dsRNA target recognition through a combination of structure and sequence. Staufen1 is a dsRBP involved in mRNA transport and localization, translational control and mRNA decay by a staufenmediated mRNA decay (SMD) pathway. The Staufen1 binding site (SBS) within human ADPribosylation factor1 (ARF1) 3’UTR is one such target and Staufen1 binding to the SBS regulates ARF1 cytoplasmic mRNA levels by the SMD pathway. However, how Staufen1 recognizes specific mRNA targets is still unknown.
Název v anglickém jazyce
Staufen1 reads out structure and sequence features in ARF1 SBS for specific target recognition
Popis výsledku anglicky
Most posttranscriptional regulation of gene expression is based on RNA elements in mRNAs recognized by RNAbinding proteins (RBPs). Besides primary sequence elements, a second layer of information is embedded in 3’UTRs of mRNAs in the form of RNA structure. Doublestranded RBPs can bind structures in 3’UTRs and then exert their function based on dsRNA target recognition through a combination of structure and sequence. Staufen1 is a dsRBP involved in mRNA transport and localization, translational control and mRNA decay by a staufenmediated mRNA decay (SMD) pathway. The Staufen1 binding site (SBS) within human ADPribosylation factor1 (ARF1) 3’UTR is one such target and Staufen1 binding to the SBS regulates ARF1 cytoplasmic mRNA levels by the SMD pathway. However, how Staufen1 recognizes specific mRNA targets is still unknown.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
10608 - Biochemistry and molecular biology
Návaznosti výsledku
Projekt
<a href="/cs/project/GA18-08153S" target="_blank" >GA18-08153S: Molekulární podstata Staufen zprostředkované funkce 3'UTR</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů