Monitoring Progress of Parkinson's Disease Based on Changes in Phonation: a Pilot Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00108633" target="_blank" >RIV/00216224:14740/18:00108633 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26220/18:PU128446

Výsledek na webu

<a href="http://dx.doi.org/10.1109/TSP.2018.8441307" target="_blank" >http://dx.doi.org/10.1109/TSP.2018.8441307</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/TSP.2018.8441307" target="_blank" >10.1109/TSP.2018.8441307</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Monitoring Progress of Parkinson's Disease Based on Changes in Phonation: a Pilot Study

Popis výsledku v původním jazyce

Hypokinetic dysarthria (HD) is a frequent symptom of idiopathic Parkinson's disease (PD). Although it is hypothesized its progress is tightly linked with changes in other motor/non-motor features of PD, it has not been proved yet. The aim of this work is to employ acoustic analysis of sustained phonation in order to identify significant correlates between phonatory measures and motor/non-motor deficits in a two-year follow-up study. For this purpose, we repeatedly quantified a sustained vowel /a/ in 51 PD patients who were also assessed by 5 common clinical scales. In addition, a multivariate regression model was trained to predict the motor/non-motor deficits in the horizon of two years. Results suggest that mainly instability in vocal folds oscillation increases with the progress of PD and with overall cognitive decline. Based on the acoustic analysis, the change in clinical scores could be predicted with the error in the range of 11.83-19.60 %.

Název v anglickém jazyce

Monitoring Progress of Parkinson's Disease Based on Changes in Phonation: a Pilot Study

Popis výsledku anglicky

Hypokinetic dysarthria (HD) is a frequent symptom of idiopathic Parkinson's disease (PD). Although it is hypothesized its progress is tightly linked with changes in other motor/non-motor features of PD, it has not been proved yet. The aim of this work is to employ acoustic analysis of sustained phonation in order to identify significant correlates between phonatory measures and motor/non-motor deficits in a two-year follow-up study. For this purpose, we repeatedly quantified a sustained vowel /a/ in 51 PD patients who were also assessed by 5 common clinical scales. In addition, a multivariate regression model was trained to predict the motor/non-motor deficits in the horizon of two years. Results suggest that mainly instability in vocal folds oscillation increases with the progress of PD and with overall cognitive decline. Based on the acoustic analysis, the change in clinical scores could be predicted with the error in the range of 11.83-19.60 %.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/NV16-30805A" target="_blank" >NV16-30805A: Efekt neinvazivní stimulace mozku na hypokinetickou dysartrii, mikrografii a mozkovou plasticitu u pacientů s Parkinsonovou nemocí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

2018 41ST INTERNATIONAL CONFERENCE ON TELECOMMUNICATIONS AND SIGNAL PROCESSING (TSP)

ISBN

9781538646953

ISSN

—

e-ISSN

—

Počet stran výsledku

4

Strana od-do

218-221

Název nakladatele

IEEE

Místo vydání

NEW YORK

Místo konání akce

Athens, GREECE

Datum konání akce

4. 7. 2018

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000454845100051