Monitoring Progress of Parkinson’s Disease Based on Changes in Phonation: a Pilot Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F18%3APU128446" target="_blank" >RIV/00216305:26220/18:PU128446 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/18:00108633

Výsledek na webu

<a href="https://ieeexplore.ieee.org/document/8441307" target="_blank" >https://ieeexplore.ieee.org/document/8441307</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1109/TSP.2018.8441307" target="_blank" >10.1109/TSP.2018.8441307</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Monitoring Progress of Parkinson’s Disease Based on Changes in Phonation: a Pilot Study

Popis výsledku v původním jazyce

Hypokinetic dysarthria (HD) is a frequent symptom of idiopathic Parkinson’s disease (PD). Although it is hypothesized its progress is tightly linked with changes in other motor/non-motor features of PD, it has not been proved yet. The aim of this work is to employ acoustic analysis of sustained phonation in order to identify significant correlates between phonatory measures and motor/non-motor deficits in a two-year follow-up study. For this purpose, we repeatedly quantified a sustained vowel /a/ in 51 PD patients who were also assessed by 5 common clinical scales. In addition, a multivariate regression model was trained to predict the motor/non-motor deficits in the horizon of two years. Results suggest that mainly instability in vocal folds oscillation increases with the progress of PD and with overall cognitive decline. Based on the acoustic analysis, the change in clinical scores could be predicted with the error in the range of 11.83–19.60 %.

Název v anglickém jazyce

Monitoring Progress of Parkinson’s Disease Based on Changes in Phonation: a Pilot Study

Popis výsledku anglicky

Hypokinetic dysarthria (HD) is a frequent symptom of idiopathic Parkinson’s disease (PD). Although it is hypothesized its progress is tightly linked with changes in other motor/non-motor features of PD, it has not been proved yet. The aim of this work is to employ acoustic analysis of sustained phonation in order to identify significant correlates between phonatory measures and motor/non-motor deficits in a two-year follow-up study. For this purpose, we repeatedly quantified a sustained vowel /a/ in 51 PD patients who were also assessed by 5 common clinical scales. In addition, a multivariate regression model was trained to predict the motor/non-motor deficits in the horizon of two years. Results suggest that mainly instability in vocal folds oscillation increases with the progress of PD and with overall cognitive decline. Based on the acoustic analysis, the change in clinical scores could be predicted with the error in the range of 11.83–19.60 %.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

20201 - Electrical and electronic engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

41st International Conference on Telecommunications and Signal Processing (TSP)

ISBN

978-1-5386-4695-3

ISSN

—

e-ISSN

—

Počet stran výsledku

4

Strana od-do

218-221

Název nakladatele

Institute of Electrical and Electronics Engineers Inc.

Místo vydání

Atény, Řecko

Místo konání akce

Athens, Greece

Datum konání akce

4. 7. 2018

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000454845100051