Fast In Vivo High-Resolution Diffusion MRI of the Human Cervical Spinal Cord Microstructure

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F19%3A00108610" target="_blank" >RIV/00216224:14740/19:00108610 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26220/19:PU129071

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-981-10-9035-6_1" target="_blank" >http://dx.doi.org/10.1007/978-981-10-9035-6_1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-981-10-9035-6_1" target="_blank" >10.1007/978-981-10-9035-6_1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fast In Vivo High-Resolution Diffusion MRI of the Human Cervical Spinal Cord Microstructure

Popis výsledku v původním jazyce

Diffusion Magnetic Resonance Imaging (dMRI) is a widely-utilized method for assessment of microstructural properties in the central nervous system i.e., the brain and spinal cord (SC). In the SC, almost all previous human studies utilized Diffusion Tensor Imaging (DTI), which cannot accurately model areas where white matter (WM) pathways cross or diverge. While High Angular Diffusion Resolution Imaging (HARDI) can overcome some of these limitations, longer acquisition times critically limit its applicability to clinical human studies. In addition, previous human HARDI studies have used limited spatial resolution, with typically a few slices and voxel size similar to 1 x 1 x 5 mm(3) being acquired in tens of minutes. Thus, we have optimized a novel fast HARDI protocol that allows collecting dMRI data at high angular and spatial resolutions in clinically-feasible time. Our data was acquired, using a 3T Siemens Prisma scanner, in less than 9 min. It has a total of 75 diffusion-weighted volumes and high spatial resolution of 0.67 x 0.67 x 3 mm(3) (after interpolation in Fourier space) covering the cervical segments C4-C6. Our preliminary results demonstrate applicability of our technique in healthy individuals with good correspondence between low fractional anisotropy (FA) gray matter areas from the dMRI scans, and the same regions delineated on T2-weighted MR images with spatial resolution of 0.35 x 0.35 x 2.5 mm(3). Our data also allows the detection of crossing fibers that were previously shown in vivo only in animal studies.

Název v anglickém jazyce

Fast In Vivo High-Resolution Diffusion MRI of the Human Cervical Spinal Cord Microstructure

Popis výsledku anglicky

Diffusion Magnetic Resonance Imaging (dMRI) is a widely-utilized method for assessment of microstructural properties in the central nervous system i.e., the brain and spinal cord (SC). In the SC, almost all previous human studies utilized Diffusion Tensor Imaging (DTI), which cannot accurately model areas where white matter (WM) pathways cross or diverge. While High Angular Diffusion Resolution Imaging (HARDI) can overcome some of these limitations, longer acquisition times critically limit its applicability to clinical human studies. In addition, previous human HARDI studies have used limited spatial resolution, with typically a few slices and voxel size similar to 1 x 1 x 5 mm(3) being acquired in tens of minutes. Thus, we have optimized a novel fast HARDI protocol that allows collecting dMRI data at high angular and spatial resolutions in clinically-feasible time. Our data was acquired, using a 3T Siemens Prisma scanner, in less than 9 min. It has a total of 75 diffusion-weighted volumes and high spatial resolution of 0.67 x 0.67 x 3 mm(3) (after interpolation in Fourier space) covering the cervical segments C4-C6. Our preliminary results demonstrate applicability of our technique in healthy individuals with good correspondence between low fractional anisotropy (FA) gray matter areas from the dMRI scans, and the same regions delineated on T2-weighted MR images with spatial resolution of 0.35 x 0.35 x 2.5 mm(3). Our data also allows the detection of crossing fibers that were previously shown in vivo only in animal studies.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2018, VOL 1

ISBN

9789811090356

ISSN

1680-0737

e-ISSN

—

Počet stran výsledku

5

Strana od-do

3-7

Název nakladatele

SPRINGER

Místo vydání

NEW YORK

Místo konání akce

Praha

Datum konání akce

1. 1. 2019

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

000450908300001